1.Department of Otolaryngology, Huai′an Hospital Affiliated to Xuzhou Medical University, Huai′an Second People′s Hospital, Jiangsu Province, Huai′an 223002, China;
2.Department of Otolaryngology, the First Affiliated Hospital of Nanjing Medical University, Jiangsu Province, Nanjing 210029, China;
3.Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Nanjing Medical University, Jiangsu Province, Nanjing 210029, China; 4.Department of Imaging, Huai′an Second People′s Hospital, Huai′an Hospital Affiliated to Xuzhou Medical University, Jiangsu Province, Huai′an 223002, China; 5.Department of Anesthesiology, Huai′an Hospital Affiliated to Xuzhou Medical University, Huai′an Second People′s Hospital, Jiangsu Province, Huai′an 223002, China
Abstract：Objective To investigate the changes and clinical significance of plasma interleukin-10 (IL-10) and vascular endothelial growth factor (VEGF) in patients with obstructive sleep apnea hypopnea syndrome (OSAHS). Methods From March 2016 to March 2019, 219 patients with OSAHS admitted to Huai′an Hospital Affiliated to Xuzhou Medical University (hereinafter referred to as “our hospital”) were selected. All OSAHS patients were monitored by polysomnography diagnostic analysis system (PSG). According to the number of sleep apnea per hour (AHI), they were divided into light OSAHS group (AHI: 5-15 times/h, n = 69), moderate OSAHS group (AHI: 16-30 times/h, n = 73), severe OSAHS group (AHI: ＞30 times/h, n = 77). During the same period, 60 volunteers who underwent physical examination in our hospital were randomly selected as the control group. PSG monitoring indexes of each group were compared, plasma IL-10 and VEGF levels in each group were compared, the correlation of VEGF and IL-10 with general data and PSG monitoring indicators were analyzed by multiple stepwise regression. Results The proportion of AHI, oxygen saturation index (ODI) and blood oxygen saturation (SaO2) ≤90% in the light, medium and heavy OSAHS groups were higher than those in the control group, and increased in turn (P ＜ 0.05). The lowest SaO2 (LSaO2) of the OSAHS light, medium and heavy groups were lower than those of the control group and showed a downward trend in turn (P ＜ 0.05). VEGF in the light, medium and heavy OSAHS groups were higher than those in the control group, and showed an ascending trend (P ＜ 0.05), IL-10 in light, medium and heavy OSAHS groups were lower than those in the control group and showed a decreasing trend (P ＜ 0.05). The results of multiple stepstep regression analysis showed that VEGF was negatively correlated with LSaO2 (r = -0.386, P ＜ 0.05), positive correlation with Epworth sleepiness scale - score (r = 0.427, P ＜ 0.01); IL-10 was positively correlated with LSaO2 (r = 0.461, P ＜ 0.01), it was negatively correlated with age and AHI (r = -0.402, -0.452, P ＜ 0.05 or P ＜ 0.01). Conclusion Abnormal expression of plasma IL-10 and VEGF in OSAHS patients can lead to vascular dysplasia, inflammatory response activation, and accelerate the disease progression of OSAHS patients.
2020, Vol. 17 
京公网安备 11010502046598号