Effect of Silibinin Capsules on metabolic index and vascular endothelial function in patients with metabolic syndrome
TAN Shixin1 LI Ming2
1.Department of Medicine, Nanjing Hospital of Traditional Chinese Medicine, Jiangsu Province, Nanjing 210006, China;
2.Department of Endocrinology, Nanjing Hospital of Traditional Chinese Medicine, Jiangsu Province, Nanjing 210006, China
Abstract：Objective To study the effect of Silibinin Capsules on metabolic index and vascular endothelial function in patients with metabolic syndrome. Methods From June 2017 to June 2019, a total of 82 patients with metabolic syndrome admitted to Nanjing Hospital of Traditional Chinese Medicine were included in the study. According to the random number table method, they were divided into control group and observation group, 41 cases in each group, the control group received basic treatment, and the observation group added Silibinin Capsules on the basis of the control group. Before and after treatment, the endothelium function indexes of the two groups were compared, basic vessel diameter (D0), congestive vessel diameter (D1), endothelium-dependent vasodilation (FMD); metabolism indexes; body mass index (BMI), waist circumference (WC), triglyceride (TG), total cholesterol (TC), fasting insulin (FINS), fasting blood glucose (FBG) and glucose metabolism rate (M); serum Inflammatory factors and liver function indexes: serum interleukin-8 (IL-8), IL-18, tumor necrosis factor-α (TNF-α), alanine aminotransferase (ALT), aspartate aminotransferase (AST). Results After treatment, FMD, D0 and D1 in the two groups were significantly higher than before treatment, and the observation group was significantly higher than the control group (P ＜ 0.05). The TG and FINS levels in both groups were significantly lower than those before treatment, and the observation group was lower than the control group (P ＜ 0.05). The M value in both groups was significantly higher than that before treatment, and the value in the observation group was higher than that in the control group (P ＜ 0.05). The levels of IL-18, IL-8, TNF-α, ALT and AST in both groups were significantly lower than those before treatment, and were lower in the observation group than in the control group (P ＜ 0.05). Conclusion Silibinin Capsules can effectively regulate metabolic disorder and improve endothelial function in patients with metabolic syndrome.
檀时新1 李鸣2. 水飞蓟宾胶囊对代谢综合征患者代谢指标及血管内皮功能的影响[J]. 中国医药导报, 2020, 17(15): 131-134.
TAN Shixin1 LI Ming2. Effect of Silibinin Capsules on metabolic index and vascular endothelial function in patients with metabolic syndrome. 中国医药导报, 2020, 17(15): 131-134.
[1] 周子丽，黄利强，梁智星，等.交感神经疾病与代谢综合征[J].广东医学，2017，38（14）：2247-2250.
[2] Mahbuba S，Mohsin F，Rahat F，et al. Descriptive epidemiology of metabolic syndrome among obese adolescent population [J]. Diabetes Metab Syndr，2018，12（3）：369-374.
[3] 何宇纳，赵文华，赵丽云，等.中国2010-2012年成年人代谢综合征流行特征[J].中华流行病学杂志，2017，38（2）：212-215.
[4] 张孔雁，曹俊杰，程燕，等.老年综合评估在老年代谢综合征患者中高血压治疗的临床效果研究[J].医学临床研究，2017，34（2）：222-225.
[5] Maslov LN，Karpov RS. Prospects for the use of cannabinoid receptor ligands for the treatment of metabolic syndrome and atherosclerosis：analysis of experimental and clinical data [J]. Vestn Ross Akad Med Nauk，2017，72（1）：59-65.
[6] Chalaya EN，Botvineva LA，Tsallagova LV，et al. The spa and health resort-based treatment of metabolic syndrome with the application of the therapeutic courses of different duration：the evaluation according long-term results [J]. Vopr Kurortol Fizioter Lech Fiz Kult，2017，94（3）：27-31.
[7] 潘长玉.代谢综合征认识和防治的新进展评《国际糖尿病联盟关于代谢综合征定义的全球共识》[J].中华内分泌代谢杂志，2005，21（4）：298-300.
[8] 新版《中国居民膳食指南》发布[J].中国食品学报，2016， 16（5）：18.
[9] 刘辉，喻红玲，柳佳利，等.建立高胰岛素血症平台对正葡萄糖钳夹试验评价胰岛素制剂PK/PD参数的影响[J].中华医学杂志，2019，99（18）：1375-1379.
[10] 周冰冰，王学梅，张茜，等.超声测量肝前脂肪厚度对诊断代谢综合征的价值[J].中国临床医学影像杂志，2017， 28（8）：560-563.
[11] 徐丽娟，庞智.粪菌移植治疗代谢综合征的研究进展[J].中华医学杂志，2018，98（7）：558-560.
[12] Yen HW，Lin HL，Hao CL，et al. Effects of pre-germinated brown rice treatment high-fat diet-induced metabolic syndrome in C57BL/6J mice [J]. Biosci Biotechnol Biochem，2017，81（5）：979-986.
[13] 王云霞.水飞蓟宾胶囊辅助用药治疗酒精性肝病伴早期肝纤维化病变的效果[J].中国实用医刊，2019，46（6）：113-116.
[14] 辛鑫，胡义扬，冯琴.水飞蓟宾治疗非酒精性脂肪性肝病研究进展[J].中西医结合肝病杂志，2018，28（3）：189-192.
[15] 曹旭丹，任春梅，和田田，等.水飞蓟宾对心肌缺血再灌注损伤大鼠心功能和氧化应激的影响[J].中国循证心血管医学杂志，2017，9（5）：573-576.
[16] 邓于亮.高血压患者胰岛素抵抗与代谢综合征、心血管事件的相关性分析[J].医学临床研究，2018，35（3）：489-491.
[17] 胡林，童焕，丁茹，等.Caco-2细胞单层模型中水飞蓟宾吸收机制研究[J].中国药科大学学报，2018，49（2）：202-208.
[18] 肖伟.分析水飞蓟宾联合复方二氯醋酸二异丙胺治疗非酒精性脂肪肝的临床效果[J].黑龙江医药，2019，32（1）：78-80.
[19] 孙双双，吴银霞，程明亮，等.水飞蓟宾-磷脂复合物干预胺碘酮诱导的小鼠脂肪肝的实验研究[J].中华肝脏病杂志，2019，27（1）：45-50.
[20] 毛翘，徐京男，崔春爱.水飞蓟宾对脂多糖诱导的小胶质细胞活性的影响[J].广东医学，2014，35（21）：3310-3312.
[21] 臧彬.恩替卡韦联合水飞蓟宾葡甲胺治疗慢性乙型肝炎合并非酒精性脂肪性肝病患者的临床疗效分析[J].当代医学，2018，24（29）：153-155.
[22] 黄维.龙胆泻肝汤联合水飞蓟宾胶囊治疗肝胆湿热型脂肪肝患者的效果观察[J].中外医学研究，2019，17（7）：52-53.
2020, Vol. 17 
京公网安备 11010502046598号