Analysis on the factors affecting the pregnancy rate of ovulatory cycle artificial insemination
ZHOU Zhi1 MA Ning1 TU Zhihua1 LI Haibo2
1.Hainan Maternal and Child Health Hospital, Hainan Province, Haikou 570206, China;
2.Suzhou Hospital Affiliated to Nanjing Medical University, Jiangsu Province, Suzhou 215000, China
Abstract：Objective To analysis the influencing factors of success rate of intrauterine artificial insemination (IUI) in ovulation-promoting cycle. Methods A retrospective analysis of 500 cycles of ovulation-promoting IUI and clinical data of patients at Hainan Maternal and Child Health Hospital and Suzhou Hospital Affiliated to Nanjing Medical University from July 2015 to June 2017, the female age, infertility years, IUI cycle, the number of IUI times per cycle, the number of ovulation inducing scheme, the number of dominant follicles, and whether or not human chorionic gonadotropin (HCG) inducing ovulation and its correlation with the clinical pregnancy rate were explored. The independent factors affecting clinical pregnancy rate of IUI were analyzed by logistic regression analysis. Results A total of 117 patients were successfully pregnant after IUI, with a pregnancy rate of 23.40%. The univariate analysis showed that the effect of female age and the number of dominant follicles on the clinical pregnancy rate of IUI was significant (P < 0.05), there were no statistically significant differences in the effects of infertility years, IUI cycles, the number of IUI in each cycle, the ovulation-promoting regimen, and whether or not HCG induced ovulation on the clinical pregnancy rate of IUI (P > 0.05). logistic regression analysis showed that the age of women (OR = 2.128, 95%CI: 1.018-4.162, P < 0.05) and the number of dominant follicles (OR = 3.617, 95%CI: 0.855-7.282, P < 0.05) were independent influencing factors of the clinical pregnancy rate of IUI in the ovulation-promoting cycle. Conclusion Female age and the number of dominant follicles are key factors in the clinical pregnancy rate of the IUI during the ovulation-promoting cycle, age is a risk factor, and the number of dominant follicles is a protective factor.
周知1 马宁1 涂志华1 李海波2. 影响促排卵周期人工授精临床妊娠率的因素分析[J]. 中国医药导报, 2020, 17(15): 104-107.
ZHOU Zhi1 MA Ning1 TU Zhihua1 LI Haibo2. Analysis on the factors affecting the pregnancy rate of ovulatory cycle artificial insemination. 中国医药导报, 2020, 17(15): 104-107.
[参考文献]
[1] Whittaker A，Inhorn MC，Shenfield F. Globalised quests for assisted conception：Reproductive travel for infertility and involuntary childlessness [J]. Glob Public Health，2019，14（12）：1669-1688.
[2] Bonow MP，Donne RDD，Rosa VBD，et al. Intrauterine insemination as a primary viable option to infertile couples：evaluation of patients in a private center [J]. JBRA Assist Reprod，2019，23（4）：328-332.
[3] Soysal C，Ozmen U. Intrauterine insemination in ovulatory infertile patients [J]. Niger J Clin Pract，2018，21（10）：1374-1379.
[4] Liao S，Xiong J，Tu H，et al. Prediction of in vitro fertilization outcome at different antral follicle count thresholds combined with female age，female cause of infertility，and ovarian response in a prospective cohort of 8269 women [J]. Fertil Steril，2019，98（41）：e17470.
[5] Pakniat H，Bahman A，Ansari I. The Relationship of Pregnancy-Associated Plasma Protein A and Human Chorionic Gonadotropin with Adverse Pregnancy Outcomes：A Prospective Study [J]. J Obstet Gynaecol India，2019，69（5）：412-419.
[6] Pulliainen H，Niela-Vilén H，Ekholm E，et al. Experiences of interactive ultrasound examination among women at risk of preterm birth：a qualitative study [J]. Bmc Pregnancy Childbirth，2019，19（1）：338.
[7] Butcher MJ，Janoo J，Broce M，et al. Use of Sperm Parameters to Predict Clinical Pregnancy with Intrauterine Insemination [J]. J Reprod Med，2016，61（5-6）：263.
[8] 陈立雪，李蓉，叶荣伟.中国妇女体外受精-胚胎移植累计活产率分析[J].中国生育健康杂志，2017，28（2）：101-105.
[9] 陈娟，张真珍，付琴，等.宫腔内人工授精妊娠结局及妊娠成功率的影响因素研究[J].河北医药，2017，39（18）：2821-2823.
[10] Ghasemi M，Kordi M，Asgharipour N，et al. The effect of a positive reappraisal coping intervention and problem-solving skills training on coping strategies during waiting period of IUI treatment：An RCT [J]. Int J Reprod Biomed，2017，15（11）：687-696.
[11] Bouet PE，May-Panloup P，Descamps P. Letter to the editor/comments on "the conversion to IUI versus continuance with IVF in low responder patients [J]. Eur J Obstet Gynecol Reprod Biol，2019，232：106.
[12] Danhof NA，van Wely M，Repping S，et al. Follicle stimulating hormone versus clomiphene citrate in intrauterine insemination for unexplained subfertility：a randomized controlled trial [J]. Hum Reprod，2018，33（10）：1866-1874.
[13] Kaur J，Suri V，Gainder S，et al. Prospective randomized trial comparing efficacy of letrozole step-up protocol with letrozole plus gonadotropins for controlled ovarian stimulation and intrauterine insemination in patients with unexplained infertility [J]. Arch Gynecol Obstet，2019，5（1）：20-25.
[14] Vichinsartvichai P，Traipak K，Manolertthewan C. Performing IUI Simultaneously with hCG Administration Does Not Compromise Pregnancy Rate：A Retrospective Cohort Study [J]. J Reprod Infert，2018，19（1）：26-31.
[15] 王娟，孟敏华，李明杰.不同促排卵方案对宫腔内人工授精妊娠结局影响研究[J].中国妇幼健康研究，2017， 28（5）：565-566.
[16] Lee J，Hwang S，Lee J，et al. Effect of insemination timing on pregnancy outcome in association with female age，sperm motility，sperm morphology and sperm concentration in intrauterine insemination [J]. J Obstet Gynecol Re，2018，44（6）：1100-1106.
[17] 朱娟，马燕琳，黄元华，等.2140例不孕患者夫精宫腔内人工授精的临床效果及其影响因素[J].山东医药，2017， 57（19）：1-4.
[18] Xueli L，Yu P，Fang C，et al. Analysis of clinical pregnancy outcomes of infertile patients undergoing natural cycles and stimulate ovulation cycles of intrauterine artificial insemination by husband [J]. Chin J Obstet Gynecol Ped，2017，4（2）：1673-5250.
[19] Borges E，Zanetti BF，Setti AS，et al. FSH dose to stimulate different patient′ ages：when less is more [J]. JBRA Assist Reprod，2017，21（4）：336-342.
[20] Li HR，Li Y，Liu Y，et al. Expression and regulation of high mobility group AT-hook 1（HMGA1） during ovulation and luteinisation in rat ovary [J]. Reprod Fert Develop，2019，31（4）：698-704.
2020, Vol. 17 
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