Analysis of clinical signs and biochemical indexes of patients with phlegm-dampness polycystic ovary syndrome infertility
YANG Yanting1 HOU Lihui2 SUN Miao2 HAO Songli2
1.The First Clinical Medical College of Heilongjiang University of Chinese Medicine, Heilongjiang Province, Harbin 150040, China;
2.Department of Obstetrics and Gynecology, the First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Heilongjiang Province, Harbin 150040, China
Abstract：Objective To explore the clinical signs, sex hormones and glycolipid metabolism characteristics of patients with phlegm-dampness polycystic ovary syndrome (PCOS) infertility. Methods From January 2017 to January 2019, 126 patients with PCOS infertility first diagnosed in the gynecology clinic of the First Affiliated Hospital of Heilongjiang University of Chinese Medicine were retrospectively analzed, including 65 cases of phlegm-dampness syndrome and 61 cases of non-dampness syndrome. The general clinical characteristics and biochemical parameters of the patients were recorded, and the clinical specificity of patients with phlegm-dampness syndrome PCOS infertility was analyzed. Results General clinical features: systolic blood pressure, diastolic blood pressure, body weight, body mass index (BMI), waist circumference and hip circumference were significantly higher in the phlegm-dampness syndrome group than those in the non-dampness syndrome group, and the incidence of overweight or obesity (BMI>24 kg/m2) in the phlegm-dampness syndrome group was significantly greater than that in the non-dampness syndrome group, and the differences were statistically significant (P < 0.05). Sex hormones index: luteinizing hormone and luteinizing hormone/follicle-stimulating hormone in the phlegm-dampness syndrome group were significantly lower than those in the non-dampness syndrome group, and the differences were statistically significant (P < 0.05). Glucose and lipid metabolism index: fasting glucose, fasting insulin and insulin resistance index in the phlegm-dampness syndrome group were significantly higher than those in the non-dampness syndrome group, and the incidence of insulin resistance in the phlegm-dampness syndrome group was significantly higher than that in the non-dampness syndrome group, and the differences were statistically significant (P < 0.05). Conclusion Patients with phlegm-dampness PCOS infertility may have significant insulin resistance and higher BMI. Therefore, it is important to pay attention to the screening of glucose and lipid metabolism in patients, so as to prevent and cure long-term complications such as impaired glucose tolerance and diabetes as early as possible.
[1] Rosenfield RL，EhrmannDA. The pathogenesis of Polycystic Ovary Syndrome （PCOS）：The Hypothesis of PCOS as Functional Ovarian Hyperandrogenism Revisited [J]. Endocr Rev，2016，37（5）：467-520.
[2] Kumari S，Pankaj S，Kavita，et al. Study of adolescent girls with menstrualirregularities for polycystic ovaries and insulin resistance [J]. Evol Med Dent Sci，2015，4（32）：5472-5483.
[3] Rosenfield RL. The Diagnosis of Polycystic Ovary Syndrome in Adolescents [J]. Pediatrics，2015，136（6），1154-1165.
[4] Bellver J，Rodriguez-Tabernero L，Robles A，et al. Polycystic ovary syndrome throughout a woman′s life [J]. J AssistReprod Genet，2018，35（1）：25-39.
[5] Teede H，Deeks A，Moran L. Polycystic ovary syndrome：a complex condition with psychological，reproductive and metabolic manifestations that impacts on health across the lifespan [J]. BMC Med，2010，8：41.
[6] Guo Y，Qi Y，Yang X，et al. Polycystic Ovary Syndrome and Gut Microbiota [J]. PLoS One，2016，11（4）：e0153196.
[7] 常久，李晓君.多囊卵巢综合征中医证型分布特点的现代文献研究[J].中国性科学，2014，23（3）：60-63.
[8] 唐培培，谈勇.多囊卵巢综合征证型及证候要素分布规律的文献研究[J].江苏中医药，2017，49（1）：66-68.
[9] 杨倩.女性性激素水平检测对多囊卵巢综合征中医证型判断的指导价值[J].四川中医，2016，34（7）：66-68.
[10] Rotterdam ESHRE/ASRM-Sponsored PCOS consensus workshop group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome （PCOS） [J]. Hum Reprod，2004，19（1）：41-47.
[11] 罗颂平.中医妇科学[M].北京：高等教育出版社，2008.
[12] 郑筱萸.中药新药临床研究指导原则[M].北京：中国医药科技出版社，2002：385-389.
[13] 刘颖华，侯丽辉，郝松莉，等.名老中医治疗多囊卵巢综合征的用药规律研究[J].中国中医基础医学杂志，2016， 22（4）：537-538，547.
[14] Li R，Zhang Q，Yang D，et al. Prevalence of polycystic ovary syndrome in women in China：a large community-based study [J]. Hum Reprod，2013，28（9）：2562-2569.
[15] Bellver J，Martínez-Conejero JA，Labarta E，et al. Endometrial gene expression in the window of implantation is altered in obese women especially in association with polycystic ovary syndrome [J]. Fertil Steril，2011，95（7）：2335-2341.
[16] 余红英.不同年龄段多囊卵巢综合征患者胰岛素抵抗和糖脂代谢的临床分析[D].南昌：南昌大学，2016.
[17] Zhang J，Liu XF，Xu LZ，et al. Environmental risk factors for women with polycystic ovary syndrome in china：a population-basedcase-control study [J]. J Biol RegulHomeost Agents，2014，28（2）：203-211.
[18] Diamond MP，Moley KH，Pellicer A，et al. Effects of streptozotocin- and alloxan-induced diabetes mellitus on mouse follicular and early embryo development [J]. J Reprod Fertil，1989，86（1）：1-10.
[19] Coffler MS，Patel K，Dahan MH，et al. Enhanced granulosa cell responsiveness to follicle-stimulating hormone during insulin infusion in women with polycystic ovary syndrome treated with pioglitazone [J]. J Clin Endocrinol Metab，2003，88（12）：5624-5631.
[20] Rice S，Christoforidis N，Gadd C，et al. Impaired insulin-dependent glucose metabolism in granulosa-lutein cells from anovulatory women with polycystic ovanes [J]. Hum Reprod，2005，20（2）：373-381.
[21] Lian F，Chen C，Xiang S. Improvement of the oocyte quality with electroacupuncture in infertility patients of kidney deficiency pattern [J]. Chinese Acupuncture & Moxibustion，2015，35（2）：109-113.
2020, Vol. 17 
京公网安备 11010502046598号