多重感染及病毒载量对儿童呼吸道感染严重程度的影响

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摘要目的探讨多重感染及病毒载量对儿童呼吸道感染严重程度的影响。方法回顾性分析2017年12月~2018年12月于重庆市江津区中心医院就诊的呼吸道感染患儿97例，根据疾病严重程度评分（IOS）将所有患儿分为轻度组（n = 72）、中度组（n = 15）、重度组（n = 10）。所有患儿均行呼吸道病原体筛检，比较三组患儿一般情况、症状、感染情况、并发症、就诊情况、实验室相关指标及病毒载量等资料的差异。分析影响患儿病情的危险因素。结果重度组多重感染率、降钙素原（PCT）及总病毒载量显著高于其他两组，而中度组多重感染率、PCT及总病毒载量显著高于轻度组（P < 0.05）。PCT（OR = 4.951，95%CI：1.005~9.473，P = 0.003）及多重感染（OR = 1.731，95%CI：8.782~122.363，P < 0.001）是影响疾病严重程度的独立危险因素。结论 PCT及多重感染是影响呼吸道感染患儿疾病严重程度的独立危险因素，在今后的临床工作中应加以重视。

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	张慧李锋代勤韵▲

关键词 ：呼吸道感染, 儿童, 多重感染, 病毒载量

Abstract：Objective To investigate the effects of multiple infections and viral load on the severity of respiratory infections in children. Methods A retrospective analysis of 97 children with respiratory infections who were treated at the Jiangjin Central Hospital of Chongqing from December 2017 to December 2018 was carried out. All children were divided into three groups: mild group (n = 72), moderate group (n = 15) and severe group (n = 10) infections according to the severity of disease. All patients underwent respiratory pathogen screening, and the differences in general conditions, symptoms, infections, complications, visits, laboratory-related indicators, and viral load were compared among the three groups. The risk factors that affect the condition of the child were analyzed. Results The multiple infection rate, procalcitonin (PCT) and total viral load in the severe group were significantly higher than those in the other two groups. The multiple infection rate, PCT and total viral load in the moderate group were significantly higher than those in the mild group (P < 0.05). PCT (OR = 4.951, 95%CI: 1.005-9.473, P = 0.003) and multiple infections (OR = 1.731, 95%CI: 8.782-122.363, P < 0.001) were independent risk factors affecting the severity of disease. Conclusion PCT and multiple infections are independent risk factors for the severity of disease in children with respiratory tract infection, and should be taken into account in future clinical work.

Key words： Respiratory infection Child Multiple infection Viral load

基金资助:国家卫生计生委医药卫生科技发展项目（W201 6EWQT48）。

通讯作者: ▲通讯作者

引用本文:

张慧李锋代勤韵▲. 多重感染及病毒载量对儿童呼吸道感染严重程度的影响[J]. 中国医药导报, 2020, 17(15): 88-91.
ZHANG Hui LI Feng DAI Qinyun▲. Effects of multiple infections and viral load on severity of respiratory infection in children. 中国医药导报, 2020, 17(15): 88-91.

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