Abstract:Objective To analyze the risk factors of renal function damage caused by anti-hepatitis B virus drugs. Methods A total of 100 cases of chronic hepatitis B (CHB) in the Fifth Affiliated Hospital of Zhongshan University from June 2015 to June 2016 were selected as the research objects. The sex, age and medication status of all patients were recorded, and the changes of estimated glomerular filtration rate (eGFR) in all patients during treatment was observed during treatment. The incidence of renal impairment was recorded in all patients during treatment. The single factor analysis of renal function damage caused by anti-hepatitis B virus drugs was analyzed. Logistic regression model was used to analyze the multi-factor analysis of renal function damage caused by anti-hepatitis B virus drugs. Results Compared with the initial treatment, the eGFR values of all patients decreased gradually after 1, 2 and 3 years of treatment (P < 0.05). According to the condition of kidney injury, the patients were divided into kidney injury group (34 cases) and non-kidney injury group (66 cases). Univariate analysis showed that age, eGFR level, anti-hepatitis B virus drugs were associated with renal impairment in patients with CHB (P < 0.05), but there was no correlation with gender (P > 0.05). Logistic regression model was included. The results showed that age ≥40 years old, eGFR < 90 mL/(min·1.73m2) and the anti-hepatitis B virus drug Adefovir Dipivoxil (ADV) were the risk factors of renal dysfunction in CHB patients (P < 0.05). Conclusion Age≥40 years old, eGFR level <90 mL/(min·1.73m2) and anti-hepatitis B virus drugs ADV are risk factors for renal function damage in CHB patients. Clinical can pay attention to the above situation to prevent the occurrence of renal injury.
何鹏园 甘崇杰 许志杰 李春娜. 抗乙肝病毒药物致肾功能损伤的危险因素分析[J]. 中国医药导报, 2020, 17(15): 67-70.
HE Pengyuan GAN Chongjie XU Zhijie LI Chun′na. Analysis of risk factors of renal function damage induced by anti-hepatitis B virus drugs. 中国医药导报, 2020, 17(15): 67-70.