Clinical study of Prostaglandin E combined with continuous renal replacement in the treatment of sepsis with acute kidney injury
CHEN Xiaoming1 CHEN Juan2 ZHANG Lin3
1.Department of Critical Care Medicine, Hefei Binhu Hospital, Anhui Province, Hefei 230061, China;
2.Department of General Internal Medicine, Eastern District of the First Affiliated Hospital of Anhui Medical University, Anhui Province, Hefei 231600, China; 3.Department of Critical Care Medicine, Hefei First People′s Hospital, Anhui Province, Hefei 230060, China
Abstract:Objective To investigate the clinical effect of Prostaglandin E combined with continuous renal replacement therapy (CRRT) in sepsis with acute kidney injury (AKI). Methods A total of 83 patients with sepsis complicated with AKI who admitted to Hefei Binhu Hospital of Anhui Province from March 2015 to January 2019 were selected and they were divided into the control group (41 cases) and the study group (42 cases) according to the random number table method. The control group was treated with CRRT, and the study group was treated with Prostaglandin E on the basis of the control group. The clinical efficacy, inflammatory factors, kidney function indexes, clinical outcome and adverse reactions were compared between the two groups. Results The total clinical effective rate of the study group was significantly higher than that of the control group after 7 days of treatment (P < 0.05). There was no statistically significant difference in interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and high-sensitivity C-reactive protein (hs-CRP) between the two groups before treatment (P > 0.05). Compared with before treatment, Il-6, hs-CRP and TNF-α in the two groups decreased after 7 days of treatment, and the study group was lower than the control group (P < 0.05). There was no significant difference in blood urea nitrogen (BUN), serum creatinine (SCr) and cystatin (CysC) between the two groups before treatment (P > 0.05). Compared with before treatment, BUN, SCr and CysC were all increased in the two groups after 7 days of treatment, but the study group was lower than the control group (P < 0.05). The length of stay in the study group was shorter than that in the control group (P < 0.05), and there was no statistically significant difference in the case fatality rate and the incidence of adverse reactions between the two groups within 28 days (P > 0.05). Conclusion Prostaglandin E combines with CRRT in the treatment of sepsis complicated with AKI has remarkable curative effect. It can effectively alleviate kidney injury, improve the level of inflammatory factors and prognosis, and has good drug safety and high clinical application value.
陈晓明1 陈娟2 张琳3. 前列腺素E联合连续肾替代治疗脓毒症伴急性肾损伤的临床研究[J]. 中国医药导报, 2020, 17(15): 63-66,83.
CHEN Xiaoming1 CHEN Juan2 ZHANG Lin3. Clinical study of Prostaglandin E combined with continuous renal replacement in the treatment of sepsis with acute kidney injury. 中国医药导报, 2020, 17(15): 63-66,83.