Meta analysis of the relationship between the lncRNA and clinical features of gastric cancer
LI Fan1,2 WANG Yuping1,2 CHEN Zhaofeng1,2 GUO Qinghong1,2 GUAN Quanlin3 ZHOU Yongning1,2
1.Department of Digestive, the First Hospital of Lanzhou University, Gansu Province, Lanzhou 730000, China;
2.Lanzhou University Gansu Key Laboratory of Gastroenterology, Gansu Province, Lanzhou 730000, China;
3.Department of Oncology, the First Hospital of Lanzhou University, Gansu Province, Lanzhou 730000, China
Abstract：Objective To study the correlation between long non-coding RNA (lncRNA) and gastric cancer and prognosis. Methods PubMed, EMbase and Web of Science database were searched, the search ended on April 2019. According to the retrieval strategy and inclusion and exclusion criteria, the literatures were screened and the relevant data were extracted. Stata software was used for meta analysis. Results Eighteen literatures were included in this study. The risk of gastric cancer in the group with high expression of lncRNA was 1.510 times than that of the group with low expression of lncRNA (HR = 1.510, 95%CI: 1.213-1.878, P = 0.000). Meta-analysis showed that there was publication bias in the literature. LncRNA expression level and TNM stage of gastric cancer patients (HR = 1.981, 95%CI: 1.458-2.692, P = 0.000), tumor differentiation degree (HR = 1.273, 95%CI: 1.103-1.469, P = 0.001), invasion depth (HR = 1.862, 95%CI: 1.565-2.216, P = 0.000), lymph node metastasis (HR = 1.570, 95%CI: 1.086-2.270, P = 0.016), and distant metastasis (HR = 2.581, 95%CI: 1.503-4.430, P = 0.001) were significantly correlated. Conclusion lncRNA is associated with poor prognosis and clinicopathological features in patients with gastric cancer, so it may be an important biomarker for gastric cancer patients. However, its clinical application still needs to be verified through more researches in the future.
李璠1，2 王玉平1，2 陈兆峰1，2 郭庆红1，2 关泉林3 周永宁1，2. lncRNA与胃癌临床特征相关性的meta分析[J]. 中国医药导报, 2020, 17(14): 90-93,105.
LI Fan1,2 WANG Yuping1,2 CHEN Zhaofeng1,2 GUO Qinghong1,2 GUAN Quanlin3 ZHOU Yongning1,2. Meta analysis of the relationship between the lncRNA and clinical features of gastric cancer. 中国医药导报, 2020, 17(14): 90-93,105.
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2020, Vol. 17 
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