Evaluation of the vascular endothelium flow-mediated dilation of cavernosal artery in T2DM patients by ultrasound
LI Jinbing1 LIU Qiang2 SHU Shengchun1 CHEN Sinan1 TANG Xianyu3
1.Department of Ultrasonography, the Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangdong Province, Guangzhou 510120, China; 2.Department of Imaging, the Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangdong Province, Guangzhou 510120, China;
3.Department of Endocrinology, the Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangdong Province, Guangzhou 510120, China
Abstract：Objective To investigate the changes in vascular endothelium flow-mediated dilation (FMD) of cavernosal artery (CA) in patients with type 2 diabetes mellitus (T2DM). Methods From March to November 2019, 54 cases with T2DM who were outpatient or in-patient in the Guangdong Provincial Hospital of Traditional Chinese Medicine were selected. According to the questionnaire score of the intemational index of erectile function 5, they were divided into T2DM with erectile dysfunction（T2DMED）group (≤21 points) 29 cases and T2DM with normal erectile function（T2DMNEF）group (22-25 points) 25 cases. Meanwhile, 25 volunteers with normal penile erection function were selected as control group. The diameter (D), peak systolic velocity (PSV) and mean flow velocity (Vmean) of CA in three groups were measured by color doppler ultrasound before and after the reactive hyperemia, and FMD, the change rate of peak systolic velocity (CRPSV) and the change rate of blood flow volume (CRVol) were calculated after the reactive hyperemia. Results Endothelial FMD of CA in T2DMNEF group and T2DMED group were lower than those in control group, and FMD in T2DMED group was lower than that in T2DMNEF group, and the differences were highly statistically significant (all P < 0.01). There were no statistically significant differences in CRPSV and CRVol of CA between T2DMNEF group and control group (P > 0.05), while CRPSV and CRVol of CA in T2DMED group were lower than those in T2DMNEF group and control group, and the differences were highly statistically significant (all P < 0.01). Conclusion Endothelial FMD of CA is impaired in T2DM patients. With the occurrence of ED in patients with T2DM, the damage to CA vascular endothelial function is also aggravated.
李进兵1 刘强2 舒盛春1 陈思楠1 唐咸玉3. 超声评价T2DM患者阴茎海绵体动脉血管内皮舒张功能[J]. 中国医药导报, 2020, 17(13): 157-159,163.
LI Jinbing1 LIU Qiang2 SHU Shengchun1 CHEN Sinan1 TANG Xianyu3. Evaluation of the vascular endothelium flow-mediated dilation of cavernosal artery in T2DM patients by ultrasound. 中国医药导报, 2020, 17(13): 157-159,163.
[1] Mahbub MI，Kamrul-Hasan AB，Selim S，et al. Frequency and Predictors of Erectile Dysfunction in Bangladeshi Men with Type 2 Diabetes Mellitus：Experience from a Tertiary Center [J]. Mymensingh Med J，2019，28（1）：137-143.
[2] Azad AK，Setunge S，Selim S，et al. Dyslipidaemia as a risk factor for erectile dysfunction in type 2 diabetes mellitus patients [J]. Diabetes Metab Syndr，2019，13（1）：748-753.
[3] Yang G，Pan C，Lu J. Prevalence of erectile dysfunction among Chinese men with type 2 diabetes mellitus [J]. Int J Impot Res，2010，22（5）：310-317.
[4] Lu CC. Smoking habits and erectile dysfunction in type 2 diabetic patients [J]. J Sex Med，2010，7（4 Pt 1）：1593.
[5] 王晓峰.男科疾病诊治进展[M].北京：人民军医出版社，2012：90.
[6] Thomas T，Andreas MZ，Stephan F. The endothelium and inflammation [J]. Endothelium，2006，13（6）：423-429.
[7] Furuta M，Tsunoda K，Arita M，et al. Endothelium-dependent vasodilation in type Ⅱ diabetes mellitus [J]． Rinsho Byori，2003，51（11）：1111-1115.
[8] Yu XH，Zhao J，Zhang SC，et al. The impact of age，BMI and sex hormone on aging males′symptoms and the international index of erectile function scores [J]. Aging Male，2017，20（4）：235-240.
[9] 贾伟平.中国2型糖尿病防治指南（2017年版）[J].中国实用内科杂志，2018，38（4）：292-344.
[10] Virag R，Floresco J，Richard C. Impairment of shear stress-mediated vasodilatation of cavernous arteries in erectile dysfunction [J]. Int J Impot Res，2004，16（1）：39-42.
[11] 沈莹莹，杜宜纲，朱磊，等.基于向量速度的超声血流量计算方法探讨[J].中国医疗器械信息，2019，24（1）：25-28.
[12] 汤峥丽，张晓，王芳.糖尿病患者的血管内皮功能、动脉将硬度和颈动脉粥样硬化的变化[J].中华高血压杂志，2016，24（12）：1175-1178.
[13] Mazo E，Gamidov S，Anranovich S，et al. Testing endothelial function of brachial and cavernous arteries in patients with erectile dysfunction [J]. J Sex Med，2006，3（2）：323-330.
[14] Castela ?魦，Costa C. Molecular mechanisms associated with diabetic endothelial-erectile dysfunction [J]. Nat Rev Urol，2016，13（5）：266-274.
[15] Behrendt D，Ganz P. Endothelial function. From vascular biology to clinical applications [J]. Am J Cardiol，2002， 90（10C）：40L-48L.
[16] 郭应禄，胡礼全.男科学[M]，北京：人民卫生出版社，2004，30.
[17] Costa C，Virag R. The Endothelial–Erectile Dysfunction Connection：An Essential Update [J]. J Sex Med，2009，6（9）：2390-2404.
[18] Gurbuz N，Sagdic G，Sanli A，et al. Therapeutic effect of combination of alagebrium （ALT-711） and sildenafil on erectile function in diabetic rats [J]. Int J Impot Res，2012，24（3）：114-121.
[19] Sopko NA，Hannan JL，Bivalacqua TJ. Understanding and targeting the Rho kinase pathway in erectile dysfunction [J]. Nat Rev Urol，2014，11（11）：622-628.
[20] 邓伟民，孙大林，金保方.糖尿病性勃起功能障碍发病机制研究进展[J].中华外科学杂志，2018，39（1）：73-75.
[21] 李红梅，李淑华，高斌，等.益肾汤对糖尿病大鼠阴茎一氧化氮合酶活性影响的实验研究[J].临床和实验医学杂志，2008，7（3）：74.
[22] 马登扬，孙霞，刘安全，等.伐地那非联合十一酸睾酮对糖尿病性勃起功能障碍患者雄激素及血管内皮功能的影响[J].中国现代医生，2019，57（19）：114-117.
[23] 叶妙勇，赵凡，马轲，等.静脉注射针与自制PE-50管针头用于大鼠阴茎海绵体内压测定的比较[J].中国实验动物学报，2019，27（6）：753-759.
[24] 李进兵，吕立国，覃勇，等.糖尿病性勃起功能障碍患者阴茎血管形态及血流动力学改变[J].中国老年学杂志，2012，32（12）：2468-2470.
2020, Vol. 17 
京公网安备 11010502046598号