Statistical analysis of white matter changes in patients with chronic obstructive pulmonary disease and subclinical cognitive impairment based on voxel analysis
WANG Chunrong1 LIU Yong2 ZHAN Yafeng3 GAO Dehong1 ZOU Liqiu1 PENG Kewen1 CHEN Jiming4 QIU Shijun5
1.Department of Radiology, Huazhong University of Science and Technology Union Shenzhen Hospital, Guangdong Province, Shenzhen 518052, China; 2.Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China;
3.School of Biomedical Engineering, Southern Medical University, Guangdong Province, Guangzhou 510515, China;
4.Department of Respiration, Huazhong University of Science and Technology Union Shenzhen Hospital, Guangdong Province, Shenzhen 518052, China; 5.Department of Radiology, the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Province, Guangzhou 510405, China
Abstract：Objective To investigate the changes of white matter structure in patients with stable subclinical cognitive impairment chronic obstructive pulmonary disease (COPD). Methods From July 2012 to March 2015, 60 patients with COPD treated in Huazhong University of Science and Technology Union Shenzhen Hospital (hereinafter referred to as “our hospital”) were selected as the COPD group, while a total of 62 healthy people who underwent a physical examination in our hospital during the same period were selected as the control group. The general data, physiological and neuropsychological data of the two groups were collected, while the changes in the whole brain white matter microstructure of the two groups were analyzed by the voxel level analysis (VBA). Results The smoking time of the COPD group was longer than that of the control group, and the difference was statistically significant (P ＜ 0.05). The total scores of mini mental state examination, Montreal cognitive assess ment and the visual space and executive function, naming and delayed memory scores were significantly lower than those of the control group, the differences were statistically significant (P ＜ 0.05). In the COPD group, the white matter FA values in the left middle occipital gyrus, right auxiliary motor area, left superior temporal gyrus, and right posterior cerebellar area were significantly lower than those in the control group, and the differences were highly statistically significant (P ＜ 0.01). Conclusion FA value of the white matter in patients with COPD in the stable phase is abnormal, and the microstructural integrity of the fibers is destroyed, which should be paid attention to clinically.
[1] Hu X，Wang H，Tu Y，et al. Alteration of the default mode network and cognitive impairments in patients with chronic obstructive pulmonary disease [J]. Int J Chron Obstruct Pulmon Dis，2018，13：519-528.
[2] Wang C，Ding Y，Shen B，et al. Altered Gray Matter Volume in Stable Chronic Obstructive Pulmonary Disease with Subclinical Cognitive Impairment：an Exploratory Study [J]. Neurotox Res，2017，31（4）：453-463.
[3] Ryu CW，Jahng GH，Choi CW，et al. Microstructural change of the brain in chronic obstructive pulmonary disease：a voxel-based investigation by MRI [J]. COPD，2013，10（3）：357-366.
[4] 张曦，张静娜，秦显莉，等.慢性阻塞性肺疾病患者脑白质微结构变化的初步研究[J].重庆医科大学学报，2017， 42（12）：1639-1643.
[5] Zhang H，Wang X，Lin J，et al. Grey and white matter abnormalities in chronic obstructive pulmonary disease：a case-control study [J]. BMJ Open，2012，2（2）：1-10.
[6] Dodd JW，Chung AW，Van Den Broek MD，et al. Brain structure and function in chronic obstructive pulmonary disease：a multimodal cranial magnetic resonance imaging study [J]. Am J Respir Crit Care Med，2012，186（3）：240-245.
[7] Lajiness-O′neill R，Akamine Y，Bowyer SM. Treatment effects of fast forword demonstrated by magnetoencephalography （MEG） in a child with developmental dyslexia [J]. Neurocase，2007，13（5）：390-401.
[8] Kim JH，Lee JM，Jo HJ，et al. Defining functional SMA and pre-SMA subregions in human MFC using resting state fMRI：functional connectivity-based parcellation method [J]. Neuroimage，2010，49（3）：2375-2386.
[9] Morgan VL，Mishra A，Newton AT，et al. Integrating functional and diffusion magnetic resonance imaging for analysis of structure-function relationship in the human language network [J]. PLoS One，2009，4（8）：1-8.
[10] Lu CQ，Xu W，Zeng CH，et al. Altered amplitude of low-frequency fluctuation in basal ganglia correlates to pulmonary ventilation function in COPD patients：A resting-state fMRI study [J]. Brain Behav，2019，9（7）：e01336.
[11] Savage CC，Dixey PHA，Pennington C，et al. Visual rating assessment of cerebral atrophy and its relationship with cognitive function in chronic obstructive pulmonary disease [J]. BMJ Open Respir Res，2018，5（1）：e000310.
[12] 闫俊，朱葛敏，屈晓一，等.慢性阻塞性肺疾病患者脑白质疏松及认知功能改变的研究[J].实用医学杂志，2018，34（21）：3513-3516.
[13] Schraa-Tam CK，Rietdijk WJ，Verbeke WJ，et al. fMRI activities in the emotional cerebellum：a preference for negative stimuli and goal-directed behavior [J]. Cerebellum，2012，11（1）：233-245.
[14] Dai XJ，Gong HH，Wang YX，et al. Gender differences in brain regional homogeneity of healthy subjects after normal sleep and after sleep deprivation：a resting-state fMRI study [J]. Sleep Med，2012，13（6）：720-727.
[15] Van Dijk EJ，Vermeer SE，De Groot JC，et al. Arterial oxygen saturation，COPD，and cerebral small vessel disease [J]. J Neurol Neurosurg Psychiatry，2004，75（5）：733-736.
[16] Kamba M，Inoue Y，Higami S，et al. Cerebral metabolic impairment in patients with obstructive sleep apnoea：an independent association of obstructive sleep apnoea with white matter change [J]. J Neurol Neurosurg Psychiatry，2001，71（3）：334-339.
[17] Alexandre FHN，Varray A. Is nocturnal desaturation a trigger for neuronal damage in chronic obstructive pulmonary disease? [J]. Med Hypotheses，2015，84（1）：25-30.
[18] Longstreth WT，Arnold AM，Manolio TA，et al. Clinical correlates of ventricular and sulcal size on cranial magnetic resonance imaging of 3,301 elderly people. The Cardiovascular Health Study. Collaborative Research Group [J]. Neuroepidemiology，2000，19（1）：30-42.
[19] Cleutjens F，Ponds R，Spruit MA，et al. The relationship between cerebral small vessel disease，hippocampal volume and cognitive functioning in patients with COPD：An MRI Study [J]. Front Aging Neurosci，2017，9：88.
[20] Wang X，Huang X，Gao Z，et al. Vasogenic cerebral edema associated with the disability in activities of daily living in patients with chronic obstructive pulmonary disease [J]. Brain Behav，2018，8（8）：e01065.
2020, Vol. 17 
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