Clinical study of Th1/Th2/Treg/Th17 immune response in patients with tuberculosis
CHENG Tao1 WU Weiling2 HUANG He3
1.Department of Infectious Disease, 458th Hospital of PLA, Guangdong Province, Guangzhou 510602, China;
2.Department of Respiratory Medicine, 458th Hospital of PLA, Guangdong Province, Guangzhou 510602, China;
3.Guangdong Academic Exchange Center of Medical Sciences Guangdong Medical Information Institute, Guangdong Province, Guangzhou 510180, China
Abstract：Objective To study Th1/Th2/Treg/Th17 immune response in patients with tuberculosis. Methods Patients with recurrent tuberculosis and primary tuberculosis who received treatment in 458th Hospital of PLA during May 2013 to October 2016 were selected as recurrent tuberculosis group (n=38) and primary tuberculosis group (n=47) respectively; healthy volunteers who received physical examination during the same period were selected as control group (n=50). The contents of Th1, Th2, Treg and Th17 cells as well as corresponding cytokines in peripheral blood, and the contents of inflammatory mediators in serum were determined. Results Th1 and Th17 cell contents as well as IFN-γ contents inperipheral blood of recurrent tuberculosis group and primary tuberculosis group were significantly lower than those of control group while Th2 and Treg cell contents as well as IL-4, IL-5, IL-10, IL-17, TGF-β, HMGB1, sTREM1, MCP1 and HBD2 contents were significantly higher than those of control group(P < 0.05); Th1, Th17 cell contents as well as IFN-γ contents in peripheral blood of recurrent tuberculosis group were significantly lower than those of primary tuberculosis group while Th2, Treg cell contents as well as IL-4, IL-5, IL-10, IL-17, TGF-β, HMGB1, sTREM1, MCP1 and HBD2 contents were significantly higher than those of primary tuberculosis group(P < 0.05); HMGB1, sTREM1, MCP1 and HBD2 were negatively correlated with Th1 and Th17, positively correlated with Th2 and Treg (P < 0.05). Conclusion The change of tuberculosis is closely related to Th1/Th2/Treg/Th17 immune response imbalance.
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2017, Vol. 14 
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