光动力联合自制中药方剂浸泡治疗跖疣的效果及对患者血清TGF-β、IFN-γ、CD28及CD40水平的影响

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摘要目的观察光动力联合自制中药方剂浸泡治疗跖疣的效果及对患者血清转化生长因子-β（TGF-β）、γ-干扰素（IFN-γ）、白细胞表面分化抗原28（CD28）及白细胞表面分化抗原40（CD40）水平的影响。方法选取2018年3月～2019年3月河北省廊坊市人民医院收治的跖疣患者85例，采用抽签方式将其分为对照组（42例）和研究组（43例）。对照组采用光动力治疗，研究组在对照组的基础上采用自制中药方剂浸泡治疗。比较两组治疗前后皮损总面积，评估临床疗效，比较两组治疗前后血清TGF-β、IFN-γ水平及CD28、CD40占比，比较两组副作用、复发情况。结果两组治疗后皮损总面积均小于治疗前，且研究组小于对照组，差异有统计学意义（P ＜ 0.05）。研究组临床疗效优于对照组，差异有统计学意义（P ＜ 0.05）。两组治疗后血清TGF-β水平低于治疗前，且研究组低于对照组，差异有统计学意义（P ＜ 0.05）；两组治疗后血清IFN-γ水平高于治疗前，且研究组高于对照组，差异有统计学意义（P ＜ 0.05）。两组治疗后血清CD28占比低于治疗前，且研究组低于对照组，差异有统计学意义（P ＜ 0.05）；两组治疗后血清CD40占比高于治疗前，且研究组高于对照组，差异有统计学意义（P ＜ 0.05）。两组副作用发生率比较差异无统计学意义（P ＞ 0.05）。随访3个月，研究组复发率低于对照组，差异有统计学意义（P ＜ 0.05）。结论光动力联合自制中药方剂浸泡治疗跖疣，可缩小皮损面积，减轻炎性反应，改善免疫功能，复发率低，疗效明显优于单纯光动力治疗。

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	孙焱

关键词 ：光动力, 自制中药方剂浸泡, 跖疣, 转化生长因子-&beta, &gamma, -干扰素, 白细胞表面分化抗原28, 白细胞表面分化抗原40

Abstract：Objective To observe effect of photodynamic therapy combined with self-made traditional Chinese medicine in the treatment of verruca plantaris and its influence on the levels of serum TGF-β, IFN-γ, CD28 and CD40 in patients. Methods Eighty-five cases of verruca plantaris admitted to Langfang People′s Hospital in Hebei Province from March 2018 to March 2019 were divided into control group (42 cases) and study group (43 cases) by drawing lots. Control group was treated with photodynamic therapy, and study group was treated with self-made traditional Chinese medicine on the basis of control group. Total area of skin lesions before and after treatment was compared between two groups, clinical effect was evaluated, the levels of serum TGF-β, IFN-γ, the proportion of CD28 and CD40 before and after treatment were compared between two groups, and the side effects and recurrence of two groups were compared. Results The total area of skin lesions in two groups after treatment was smaller than that before treatment, and study group was smaller than control group, the differences were statistically significant (P < 0.05). Clinical effect of study group was better than that of control group, the difference was statistically significant (P < 0.05). After treatment, the serum TGF-β level in two groups was lower than that before treatment, which in study group was lower than that in control group, the differences were statistically significant (P < 0.05). After treatment, the serum IFN-γ level of two groups was higher than that before treatment, which of study group was higher than that of control group, the differences were statistically significant (P < 0.05). The percentage of CD28 in two groups after treatment was lower than that before treatment, which in study group was lower than that in control group, the differences were statistically significant (P < 0.05). The percentage of serum CD40 in two groups after treatment was higher than that before treatment, which in study group was higher than that in control group, the differences were statistically significant (P < 0.05). There was no significant difference in incidence of side effects between two groups (P > 0.05). Follow up for 3 months, the recurrence rate of study group was lower than that of control group (P < 0.05). Conclusion Photodynamic therapy combined with traditional Chinese medicine can reduce the area of skin lesions, reduce the inflammatory reaction, improve the immune function, and reduce the recurrence rate. The curative effect of photodynamic therapy is significantly better than that of photodynamic therapy alone.

Key words： Photodynamic Self-made traditional Chinese medicine Verruca plantaris Transforming growth factor-β Interferon-γ Leukocyte surface differentiation antigen 28 Leukocyte surface differentiation antigen 40

基金资助:河北省廊坊市科技计划项目（2016013012）。

作者简介: 孙焱（1975.11-），女，副主任医师；研究方向：常见病毒性皮肤病的治疗。

引用本文:

孙焱. 光动力联合自制中药方剂浸泡治疗跖疣的效果及对患者血清TGF-β、IFN-γ、CD28及CD40水平的影响[J]. 中国医药导报, 2020, 17(12): 192-196.
SUN Yan. Effect of photodynamic therapy combined with self-made traditional Chinese medicine in the treatment of verruca plantaris and its influence on the levels of serum TGF-β, IFN-γ, CD28 and CD40 in patients. 中国医药导报, 2020, 17(12): 192-196.

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http://www.yiyaodaobao.com.cn/CN/ 或 http://www.yiyaodaobao.com.cn/CN/Y2020/V17/I12/192

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