The relationship between the serum uric acid level of different genders and the degree of coronary heart disease and coronary artery stenosis
LI Yachao1 YANG Yanli1 AN Lei1 LIU Xinming2 LU Dianlin1 GUAN Zeyong1 XUE Zengming1▲
1.The First Department of Cardiology, Langfang People′s Hospital Affiliated to Hebei Medical University, Hebei Province, Langfang 065000, China;
2.Wards 44 in the Cardiac, Beijing Anzhen Hospital, Capital Medical University, Beijing 100000, China
Abstract：Objective To study the relationship between serum uric acid levels of different genders and the degree of coronary heart disease and coronary artery stenosis. Methods A total of 500 patients with coronary heart disease who underwent percutaneous coronary intervention (PCI) in the Department of Cardiology, Langfang people′s Hospital Affiliated to Hebei Medical University from February 2012 to February 2016 were selected as the study subjects. They were divided into the male group (280 cases) and female group (220 cases) by sex, and the standard of blood uric acid in male was ＞420 μmol/L and female was ＞357 μmol/L. The male group was divided into hyperuricemia group (115 cases) and non-hyperuricemia group (165 cases), women with hyperuricemia group (73 cases) and non-hyperuricemia group (147 cases), the degree of coronary artery stenosis in each group was compared. The presence of adverse cardiac events, basic data and related serum indicators in the male and female groups were compared, and the relationship between the basic data and the occurrence of adverse cardiac events after PCI was further analyzed by logisitic regression analysis. Results There was no significant difference in the score of coronary artery stenosis between the male hyperuricemia group and the non-hyperuricemia group (P ＞ 0.05). The score of coronary artery stenosis in the female hyperuricemia group was higher than that in the non-hyperuricemia group (P ＜ 0.05). Adverse cardiac events in the male and female groups were associated with age, smoking, hypertension and family genetic history (all P ＜ 0.05). The logistic regression analysis showed that the age (male: OR = 6.234, 95%CI: 1.375-8.385; female: OR = 7.139, 95%CI: 1.325-11.288), smoking (male: OR =10.753, 95%CI: 4.592-19.586; female: OR = 8.953, 95%CI: 2.395-14.275), hypertension (male: OR = 8.174, 95%CI: 3.295-20.907; female: OR = 5.302, 95%CI: 1.857-8.076), family genetic history (male: OR = 7.053, 95%CI: 1.055-10.844; female: OR = 5.032, 95%CI: 1.287-9.058) were independent risk factors for adverse cardiac events after PCI in patients with coronary heart disease of different sex. The serum uric acid (OR =6.038, 95%CI: 1.405-9.17) was independent risk factors for adverse cardiac events after PCI in coronary heart disease female (P ＜ 0.05). Conclusion The serum uric acid level of female patients with coronary heart disease is closely related to the degree of coronary artery stenosis and adverse cardiac events after PCI.
李雅超1 杨彦立1 安蕾1 刘新民2 路殿林1 关泽勇1 薛增明1▲. 不同性别血尿酸水平与冠心病及冠状动脉狭窄程度的关系[J]. 中国医药导报, 2020, 17(11): 128-131.
LI Yachao1 YANG Yanli1 AN Lei1 LIU Xinming2 LU Dianlin1 GUAN Zeyong1 XUE Zengming1▲. The relationship between the serum uric acid level of different genders and the degree of coronary heart disease and coronary artery stenosis. 中国医药导报, 2020, 17(11): 128-131.
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2020, Vol. 17 
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