Analysis on the treatment of acute promyelocytic leukemia with arsenic-containing agent regimen
LIU Feng1 JIA Haipeng2 DUAN Yanchao2
1.Department of Hematology, Affiliated Hospital of Guilin Medical University, Guangxi Zhuang Autonomous Region, Guilin 541001, China;
2.Department of Hematology, the Second Affiliated Hospital of Shandong First Medical University, Shandong Province, Tai′an 271000, China
Abstract：Objective To retrospectively analyze the difference in clinical efficacy and cost between Arsenic-containing agent and non-arsenic-containing agent in patients with acute promyelocytic leukemia. Methods From December 2012 to December 2016, a total of 27 cases of adult acute promyelocytic leukemia patients primary treated in Affiliated Hospital of Guilin Medical University were selected. According to the different induction program, they were divided into observation group (12 cases) and control group (15 cases). The observation group was treated with arsenic-containing agent and the control group was treated with non-arsenic-containing agent. The differences of efficacy and adrerse reactions, blood dosage and medical expenses between the two groups were compared. Results There was no statistically significant difference between the two groups in the rates of complete remission, the time required to obtain CR, the 2-year overall survival rate, the dosage of red blood cells, platelets and plasma, the duration of treatment, and the cost of treatment (all P > 0.05). Conclusion The efficacy and cost of induction therapy in patients with acute promyelocytic leukemia with arsenic-containing agent is similar to that with non-arsenic-containing agent, but it′s necessary to study the large size sample further.
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2020, Vol. 17 
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