Abstract：Objective To investigate the relationship between serum soluble PD-1 (sPD-1) level and carotid atherosclerotic plaque in type 2 diabetes mellitus （T2DM） patients. Methods From October 2016 to March 2019，100 cases with T2DM patients who admitted to the First People′s Hospital of Nanning of Guangxi Zhuang Autonomous Region were selected. According to the presence or absence of carotid atherosclerotic plaque, they were divided into plaque group (54 cases) and non-plaque group (46 cases). General information, biochemical index and the serum sPD-1 level and carotid Crouse integral of two groups were compared. Logistic regression analysis was used for multivariate analysis. Results The systolic blood pressure level and the proportion of smoking and drinking in plaque group were higher than those in non-plaque group (P < 0.05). The C-reactive protein, triacylglycerol levels in plaque group were higher than those in non-plaque group (P < 0.05). Serum sPD-1 levels and carotid Crouse integral in plaque group were higher than those in non-plaque group (P < 0.05), and serum sPD-1 level was positively correlated with carotid Crouse integral (r = 0.384, P = 0.023). Logistic regression analysis showed that smoking, drinking, C-reactive protein and sPD-1 level were independent risk factors for carotid atherosclerotic plaque formation in T2DM patients (P < 0.05). ROC curve analysis showed that the critical value of sPD-1 was 1.41 ng/mL, the area under the curve was 0.824, the sensitivity was 81.24%, the specificity was 78.79% (95%CI:0.669-0.979，P = 0.027). Conclusion Serum sPD-1 level may all increase the risk of carotid atherosclerotic plaque formation in T2DM patients. Monitoring serum sPD-1 level can be used to diagnose carotid atherosclerotic plaque.
2020, Vol. 17 
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