Abstract：Objective To investigate the clinical effects and adverse reactions of Peramivir Sodium Chloride Injection in the treatment of children with influenza and pneumonia. Methods A total of 100 children hospitalized in Hebei Children′s Hospital from November 2018 to March 2019 were collected and divided into the control group and the observation group according to the random number table method, with 50 cases in each group. The control group was treated with Oseltamivir Phosphate Granules, and the observation group was treated with Peramivir Sodium Chloride Injection. The clinical efficacy, total effective rate, viral antigen negative conversion rate, adverse reactions and blood routine changes after 5 days of the two groups during the treatment were compared. Results The duration of fever, cough, lung rales and hospital stay in the observation group were significantly shorter than those in the control group, with statistically significant differences (all P ＜ 0.05). However, there was no statistically significant difference in the duration of pharyngeal congestion between the two groups (P ＞ 0.05). The total effective rate and viral antigen negative conversion rate of the observation group were higher than those of the control group, with statistically significant differences (all P ＜ 0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (P ＞ 0.05). There was no statistically significant difference between the two groups in blood routine indexes before treatment (P ＞ 0.05). After 5 days of treatment, the percentage of neutrophils in the two groups was significantly higher than before treatment, and the observation group was higher than the control group, while the C-reactive protein was significantly lower than before treatment, and the observation group was lower than the control group, with statistically significant differences (all P ＜ 0.05). Platelets were higher in the control group 5 days after treatment than before treatment, and the difference was statistically significant (P ＜ 0.05). However, there was no statistically significant difference in white blood cells, red blood cells, the percentage of lymphocytes and platelets between the two groups after 5 days of treatment (P ＞ 0.05). Conclusion In the treatment of children with influenza and pneumonia, the clinical effect of Peramivir is better than Oseltamivir, can improve the total effective rate, shorten the hospital stay, and the virus antigen conversion rate is higher, blood routine to normal value is more obvious, the effect is fast, worthy of clinical promotion.
安志华1 张古英1 东蕾1 贾晨虹1 付海燕2. 帕拉米韦治疗儿童流感合并肺炎的效果[J]. 中国医药导报, 2020, 17(10): 153-156.
AN Zhihua1 ZHANG Guying1 DONG Lei1 JIA Chenhong1 FU Haiyan2. Effect of Peramivir in the treatment of children with influenza and pneumonia. 中国医药导报, 2020, 17(10): 153-156.
2020, Vol. 17 
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