Abstract：Objective To investigate the clinical effect of puerarin combined with α-lipoic acid in the treatment of diabetes mellitus with carotid atherosclerosis. Methods A total of 122 patients with diabetes mellitus complicated with carotid atherosclerosis admitted to Ansteel Group Hospital from January 2015 to January 2019 were selected and they were divided into the control group and the study group according to the random number table method, with 61 cases in each group. The control group was treated with α-lipoic acid on the basis of routine treatment, and the study group was treated with α-lipoic acid on the basis of the control group. The clinical efficacy, glucose and lipid metabolism indexes and oxidative stress indexes of the two groups were compared, and the occurrence of adverse reactions of the two groups during treatment was recorded. Results After one month of treatment, the total clinical effective rate of the study group was higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). Before treatment, there was no statistically significant difference between the two groups in glycosylated hemoglobin (HbA1c), total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL) and high-density lipoprotein (HDL) (P ＞ 0.05). After one month of treatment, there was no significant difference in HbA1c between the two groups (P ＞ 0.05). In both groups, TC, TG and LDL decreased and HDL increased compared with that before treatment, and TC, TG and LDL in the study group were lower than those in the control group and HDL was higher than those in the control group, with statistically significant differences (all P ＜ 0.05). There was no statistically significant difference in serum superoxide dismutases (SOD) and malondialdehyde (MDA) levels between the two groups before treatment (P ＞ 0.05). After one month of treatment, SOD increased and MDA decreased in the two groups, and SOD in the study group was higher than that in the control group, while MDA was lower than that in the control group, with statistically significant differences (all P ＜ 0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (P ＞ 0.05). Conclusion Puerarin combined with α-lipoic acid in the treatment of diabetes mellitus with carotid atherosclerosis has a significant effect, and can effectively improve the level of blood lipid and oxidative stress index in patients, with a good safety and high clinical application value.
何桂香1 马云辉2 刘海燕1 钟怡3. 葛根素联合α-硫辛酸治疗糖尿病合并颈动脉粥样硬化的临床研究[J]. 中国医药导报, 2020, 17(10): 82-85.
HE Guixiang1 MA Yunhui2 LIU Haiyan1 ZHONG Yi3. Clinical study of puerarin combined with α-lipoic acid in the treatment of diabetes mellitus with carotid atherosclerosis. 中国医药导报, 2020, 17(10): 82-85.
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2020, Vol. 17 
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