Abstract：Objective To investigate the function of alert network in patients with Parkinson′s disease (PD). Methods From October 2016 to April 2018, 40 PD patients diagnosed in the Nanxishan Hospital of Guangxi Zhuang Autonomous Region (“our hospital” for short) were selected as the PD group, and 45 healthy adults who passed the physical examination in our hospital at the same time were selected as the control group. Attention network test software and local consistency analysis method of resting state functional magnetic resonance imaging were used to explore the alert function and resting state changes of brain function in PD patients. Results Phase alert reaction time (RT) and intrinsic alert RT in the PD group were significantly longer than those in the control group, with statistically significant differences (P ＜ 0.05). However, there was no significant difference in alert network efficiency between the two groups (all P ＞ 0.05). The results of functional magnetic resonance imaging showed that the regional homogeneity values of left cingulate gyrus and right parahippocampal gyrus in the PD group were significantly lower than those in the control group, with statistically significant differences (P ＜ 0.05). The correlation analysis found that the alert network efficiency was negatively correlated with the course of disease (r = -0.373, P ＜ 0.05), but not with educational level (r = 0.217, P ＞ 0.05) and intelligence (r = 0.113, P ＞ 0.05). Conclusion PD patients have abnormal brain function and the damage of alert behavior, which is aggravated with the progress of the course of disease. This study can lay a foundation for further exploration of cognitive function damage in PD patients in the future.
刘慧华1 蒋艳春1 刘运昌2 王源3 乔丽丽3. 帕金森病患者警觉功能静息态功能磁共振的研究[J]. 中国医药导报, 2020, 17(9): 177-180.
LIU Huihua1 JIANG Yanchun1 LIU Yunchang2 WANG Yuan3 QIAO Lili3. Study of alertness function resting-state magnetic resonance imaging in patients with Parkinson′s disease. 中国医药导报, 2020, 17(9): 177-180.
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2020, Vol. 17 
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