Clinical application of Phloroglucinolin in the process of terminating midtrimester pregnancy in scar uterus
REN Hongwei1 WANG Yan1 ZHANG Yuxiang1 ZHAO Yuan2 DOU Weina2 XING Jingna1 DING Ya1 HAN Wenfeng3
1.Department of Gynecology, the Seventh People′s Hospital of Hebei Province, Hebei Province, Dingzhou 073000, China;
2.Department of Obstetrics, the Seventh People′s Hospital of Hebei Province, Hebei Province, Dingzhou 073000, China;
3.Department of Oncology, the Seventh People′s Hospital of Hebei Province, Hebei Province, Dingzhou 073000, China
Abstract：objective To observe the clinical efficacy and safety of Phloroglucinol in the process of terminating midtrimester pregnancy in scar uterus. Methods From January 2017 to June 2019, a total of 78 cases with scar uterus who desiring to terminate midtrimesting pregnancy were selected from the Seventh People′s Hospital of Hebei Province. They were divided into observation group and control group according to the random number table method, with 39 cases in each group. In observation group, Mifepristone combined with Misoprostol were used to induce labor, and 5% glucose 250 mL plus Resorcinol 160 mg was given by intravenous infusion when the uterine orifice was 1 cm. Control group was induced by Mifepristone combined with Misoprostol. The time of induced labor, the degree of patiens pain, the laceration of soft birth canal, the success rate of terminating pregnancy, the bleeding of induced labor, and the adverse reactions were observed and recorded. Results The time of induced labor in observation group was shorter than that of control group , the degree of patiens pain was less severe than that of control group, the proportion of patients with soft birth canal laceration was lower than that of control group, the success rate of labor induction was higher than that of control group, and the differences were statistically significant (all P < 0.05). There was no statistically significant difference between the two groups in the bleeding of induced labor and the incidence of adverse reactions (P > 0.05). Conclusion When Mifepristone combined with Misoprostol are used to induce labor in terminating midtrimester pregnancy in scar uterus, the addition of Phloroglucinol is safe and effective, and can improve the success rate of labor induction, shorten labor induction time, reduce the pain of patients, and not increase the amount of blood loss, which is worthy of clinical application.
2020, Vol. 17 
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