Meta-analysis and sequential analysis of the efficacy of vitamin B1 injection in treating hyperemesis gravidarum nèiguān point (P6)
FENG Xin1 XU Zhongbo2 YE Lin1 ZHU Shuping1
1.Department of Health Education, Jiangxi Maternal and Child Health Hospital, Jiangxi Province, Nanchang 330006, China;
2.Department of Emergency, Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Jiangxi Province, Nanchang 330006, China
Abstract：Objective To study the efficacy of vitamin B1 injection at nèiguān point (P6) for hyperemesis gravidarum was evaluated by meta-analysis and sequential analysis. Methods PubMed, Embase, Cochrane Library, CMB, CNKI, WanFang and VIP datebases were searched. The retrieval time was from the database establishment to October 2019. The retrieval strategy was research object (P) + intervention measures (I) + research design (S), with the combination of subject words and free words. The literature was screened by 2 trained researchers according to the inclusion and exclusion criteria. The basic characteristics and publication deviation of the literature were observed and recorded. The meta-analysis and sequential analysis of the experiment were carried out with RevMan 5.3 software and Stata12.0 software. Results A total of 12 articles and 1247 cases were included. Meta-analysis showed that effective rate of hyperemesis gravidarum in the experimental group was higher than that in the control group, and the difference was highly statistically significant (OR = 9.21，95%CI:4.87-17.43，P ＜ 0.01). The effect of injection of vitamin B1 in nèiguān point (P6) was confirmed by sequential-analysis. Conclusion Injection of vitamin B1 into nèigu?ān point (P6) has a more obvious effect on the treatment of hyperemesis gravidarum and is easy to operate. However, due to the limitation of this study, the results may be biased, so it is necessary to be cautious in clinical application.
2020, Vol. 17 
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