氨基酸在炎症性肠病治疗中的研究进展

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摘要炎症性肠病（IBD）是一种病因尚未明确的肠道黏膜慢性非特异性炎症性疾病，包括克罗恩病和溃疡性结肠炎，其病因及发病机制尚未完全清楚，一般认为与环境、遗传、感染及免疫等多种因素有关。氨基酸是生物体内重要的营养物质，是促进肠道生长、维持肠道黏膜完整和屏障功能的必需物质，作为肠细胞的能量底物，是促进肠黏膜愈合的物质基础。大量研究证实IBD疾病过程中存在氨基酸代谢异常，包括谷氨酰胺、谷氨酸、精氨酸、色氨酸、半胱氨酸、甘氨酸等，并且补充上述氨基酸对IBD肠道损伤具有保护作用。其作用机制涉及刺激肠上皮细胞增殖，抑制氧化应激损伤，减少促炎细胞因子释放，增加上皮细胞迁移能力等。本文通过收集国内外相关文献，旨在探讨氨基酸在IBD治疗中的潜在价值。

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	蔡彬1 周敏红2 李春伟1▲

关键词 ：氨基酸, 炎症性肠病, 溃疡性结肠炎, 克罗恩病

Abstract：Inflammatory bowel disease (IBD) is a chronic non-specific inflammatory disease of the intestinal mucosa with unknown etiology, including crohn′s disease and ulcerative colitis. The etiology and pathogenesis are not completely clear, and it is generally believed to be related to environment, heredity, infection and immunity. Amino acids are important nutrients in living organisms, which are essential substances for promoting intestinal growth, maintaining intestinal mucosal integrity and barrier function. Amino acids are also energy substrates for intestinal cells and the material basis for wound healing of intestinal mucosa. A large number of studies have confirmed the abnormal amino acid metabolism in the course of IBD disease, including glutamine, glutamate, arginine, tryptophan, cysteine, glycine, etc., and the supplementation of the above amino acids has a protective effect on the intestinal damage of IBD. The mechanism involves stimulating intestinal epithelial cell proliferation, inhibiting oxidative stress damage, reducing the release of pro-inflammatory cytokines, and increasing the migration capacity of epithelial cells. This article aims to explore the potential value of amino acids in the treatment of IBD by collecting relevant literature at home and abroad.

Key words： Amino acids Inflammatory bowel disease Ulcerative colitis Crohn′s disease

基金资助:江苏省自然科学基金青年基金项目（BK201702 12）；
江苏省“六大人才高峰”C类高层次人才项目（WSN-190）。

通讯作者: ▲通讯作者

作者简介: 蔡彬（1988-），男，博士，主要从事肠道炎症性疾病的基础和临床研究工作。

引用本文:

蔡彬1 周敏红2 李春伟1▲. 氨基酸在炎症性肠病治疗中的研究进展[J]. 中国医药导报, 2020, 17(9): 37-40.
CAI Bin1 ZHOU Minhong2 LI Chunwei1▲. Research progress of amino acids in the treatment of inflammatory bowel disease. 中国医药导报, 2020, 17(9): 37-40.

链接本文:

http://www.yiyaodaobao.com.cn/CN/ 或 http://www.yiyaodaobao.com.cn/CN/Y2020/V17/I9/37

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