Abstract：Osteoarthritis is a common joint disease in orthopedics, and its prevalence is increasing with the aging of population. The pathogenesis of osteoarthritis is influenced by multiple factors, including oxidative stress and excessive production of reactive oxygen species, which regulate intracellular signal transduction, chondrocyte aging and apoptosis, extracellular matrix synthesis and degradation, synovial inflammation and subchondral bone function. Due to relatively few drugs for osteoarthritis, this paper targeting complex oxidative stress signaling pathways could provides strategies for treating osteoarthritis.
[1] Duan L，Zhang W，Zhang F，et al. Myrtol improves post-traumatic knee osteoarthritis by regulation of reactive oxygen species，transforming growth factor β1 and apoptosis in a mouse model [J]. Exp Ther Med，2018，15（1）：393-399.
[2] Qiao YQ，Jiang PF，Gao YZ. Lutein prevents osteoarthritis through Nrf2 activation and downregulation of inflammation [J]. Arch Med Sci，2018，14（3）：617-624.
[3] Akuri MC，Barbalho SM，Val RM，et al. Reflections about Osteoarthritis and Curcuma longa [J]. Pharmacogn Rev，2017，11（21）：8-12.
[4] Abusarah J，Bentz M，Benabdoune H，et al. An overview of the role of lipid peroxidation-derived 4-hydroxynonenal in osteoarthritis [J]. Inflamm Res，2017，66（Suppl 1）：1-15.
[5] Sun MG，Beier F，Pest MA. Recent developments in emerging therapeutic targets of osteoarthritis [J]. Curr Opin Rheumatol，2017，29（1）：96-102.
[6] Yang C，You D，Huang J，et al. Effects of AURKA‐mediated degradation of SOD2 on mitochondrial dysfunction and cartilage homeostasis in osteoarthritis [J]. J Cell Physiol，2019，234（10）：17727-17738.
[7] Quan YY，Xia Q，Liu YH，et al. Inhibitory Effects of Free and Nano-Liposomal-Loaded Resveratrol on Sodium Nitroprusside-Induced Rabbit Chondrocyte Apoptosis [J]. J Nanosci Nanotechnol，2017，17（3）：1740-1746.
[8] Reckziegel D，Bailey H，Cottam WJ，et al. Imaging pain relief in osteoarthritis （IPRO）：protocol of a double-blind randomised controlled mechanistic study assessing pain relief and prediction of duloxetine treatment outcome [J]. BMJ Open，2017，7（6）：e014013.
[9] Reed K，Collaku A，Moreira S. Efficacy and Safety of Twice-Daily Sustained-Release Paracetamol Formulation for Osteoarthritis Pain of the Knee or Hip：A Randomized，Double-Blind，Placebo-Controlled，Twelve-Week Study [J]. Curr Med Res Opin，2017，34（4）：1.
[10] Kapitanov GI，Ayati BP，Martin JA. Modeling the effect of blunt impact on mitochondrial function in cartilage：implications for development of osteoarthritis [J]. Peer J，2017，5（6）：e3468.
[11] Young IC，Chuang ST，Gefen A，et al. A novel compressive stress-based osteoarthritis-like chondrocyte system [J]. Exp Biol Med，2017，242（10）：1062-1071.
[12] Wu R，Li D，Tang Q，et al. A Novel Peptide from Vespa ducalis Induces Apoptosis in Osteosarcoma Cells by Activating the p38 MAPK and JNK Signaling Pathways [J]. Biol Pharm Bull，2018，41（4）：458-464.
[13] Fernández-Moreno M，Soto-Hermida A，Vázquez-Mosquera M E，et al. Mitochondrial DNA haplogroups influence the risk of incident knee osteoarthritis in OAI and CHECK cohorts. A meta-analysis and functional study [J]. Ann Rheum Dis，2017，76（6）：1114.
[14] Chen K，Yan Y，Li C，et al. Increased 15-lipoxygenase-1 expression in chondrocytes contributes to the pathogenesis of osteoarthritis [J]. Cell Death Dis，2017，8（10）：e3109.
[15] Guo YX，Liu L，Yan DZ，et al. Plumbagin prevents osteoarthritis in human chondrocytes through Nrf-2 activation [J]. Mol Med Rep，2017，15（4）：2333.
[16] Bethapudi B，Murugan S，Illuri R，et al. Bioactive Turmerosaccharides from Curcuma longa Extract （NR-INF-02）：Potential Ameliorating Effect on Osteoarthritis Pain [J]. Pharmacogn Mag，2017，13（Suppl 3）：S623-S627.
[17] Cheleschi S，De AP，Pascarelli NA，et al. Could Oxidative Stress Regulate the Expression of MicroRNA-146a and MicroRNA-34a in Human Osteoarthritic Chondrocyte Cultures? [J]. Int J Mol Sci，2017，18（12）：2660.
[18] Hosseinzadeh A，Jafari D，Kamarul T，et al. Evaluating the Protective Effects and Mechanisms of Diallyl Disulfide on Interlukin-1β-induced Oxidative Stress and Mitochondrial Apoptotic Signaling Pathways in Cultured Chondrocytes [J]. J Cell Biochem，2017，118（7）：1879-1888.
[19] Xue EX，Lin JP，Zhang Y，et al. Pterostilbene inhibits inflammation and ROS production in chondrocytes by activating Nrf2 pathway [J]. Oncotarget，2017，8（26）：41988-42000.
[20] Bahrampour KJ，Kamarul T，Najafi M，et al. Restoring the IL-1β/NF-κB-induced impaired chondrogenesis by diallyl disulfide in human adipose-derived mesenchymal stem cells via attenuation of reactive oxygen species and elevation of antioxidant enzymes [J]. Cell Tissue Res，2018，373（2）：407-419.
[21] Zhang C，Lin S，Li T，et al. Mechanical force-mediated pathological cartilage thinning is regulated by necroptosis and apoptosis [J]. Osteoarthritis Cartilage，2017，25（8）：1324-1334.
[22] Mueller AJ，Canty-Laird EG，Clegg PD，et al. Cross-species gene modules emerge from a systems biology approach to osteoarthritis [J]. NPJ Syst Biol Appl，2017，3（1）：13.
[23] Von BM，Feierabend M，Jordan M，et al. Radiographic Hip or Knee Osteoarthritis and the Ability to Drive [J]. Orthopedics，2017，40（1）：1.
[24] Yin CM，Suen WC，Lin S，et al. Dysregulation of both miR-140-3p and miR-140-5p in synovial fluid correlate with osteoarthritis severity [J]. Bone Joint Res，2017，6（11）：612-618.
[25] Wang C，Silverman RM，Jie S，et al. Distinct metabolic programs induced by TGF-β1 and BMP2 in human articular chondrocytes with osteoarthritis [J]. J Orthop Translat，2018，12（C）：66-73.
[26] Lin M，Lin Y，Li X，et al. Warm sparse-dense wave inhibits cartilage degradation in papain-induced osteoarthritis through the mitogen-activated protein kinase signaling pathway [J]. Exp Ther Med，2017，14（4）：3674-3680.
[27] Zhang L，Luan L，Ma Y. Dishevelled-2 modulates osteogenic differentiation of human synovial fibroblasts in osteoarthritis [J]. Mol Med Rep，2018，18（1）：292-298.
[28] Zheng Z，Wang L，Pan J. Estradiol and proinflammatory cytokines stimulate ISG20 expression in synovial fibroblasts of patients with osteoarthritis [J]. Intractable Rare Dis Res，2017，6（4）：269-273.
[29] Pm VDK. Factors that influence outcome in experimental osteoarthritis [J]. Osteoarthritis Cartilage，2017，25（3）：369-375.
2020, Vol. 17 
京公网安备 11010502046598号