Abstract：Objective To observe the clinical effect of hyaluronic acid repair biofilm combined with Loratadine Tablets in the treatment of atopic dermatitis and the effect on serum interleukin（IL）-2 and IL-4 levels. Methods One hundred and sixty patients with atopic dermatitis who were admitted to Cangzhou People′s Hospital from January 2017 to February 2018 were collected and divided into the control group and the observation group according to the random number table method, with 80 cases in each group. The control group was treated with Loratadine Tablets (10 mg/ time, 1 time/d). The observation group was given hyaluronic acid repair biofilm for skin care on the basis of treatment of the control group, once in the morning and once in the evening, after 4 weeks of continuous treatment. Scoring atopic dermatitis index (SCORAD), visual analogue scale (VAS), sebum content, cuticle water content, scale human tissue kallikelin 5 (KLK5), transepidermal water loss (TEWL), immature cornified envelope in scales (CE), serum IL-2, IL-4 and clinical efficacy were compared between the two groups. Results There was no significant difference in SCORAD and VAS scores before treatment between the two groups (P ＞ 0.05). Compared with before treatment, the SCORAD and VAS scores of the two groups were significantly decreased after treatment, and the SCORAD and VAS scores in the observation group were significantly lower than that in the control group, the differences were highly statistically significant (all P ＜ 0.01). There was no significant difference in sebum content, cuticle water content, KLK5 in scales, TEWL and immature CE ratio in scales between the two groups before treatment (P ＞ 0.05). Compared with before treatment, sebum content, cuticle water content and KLK5 in scales in the two groups were significantly increased after treatment, while the proportion of TEWL and immature CE in scales was significantly reduced, and the sebum content, cuticle water content and KLK5 in scales in the observation group were significantly higher than those in the control group, while the proportion of TEWL and immature CE in scales was significantly lower than that in the control group after treatment, the differences were highly statistically significant (all P ＜ 0.01). There was no significant difference in serum IL-2 and IL-4 between the two groups before treatment (P ＞ 0.05). Compared with the two groups before treatment, the serum IL-2 level significantly increased and IL-4 level significantly decreased in the two groups after treatment, and the serum IL-2 level in the observation group was significantly higher than that in the control group, while the serum IL-4 level was significantly lower than that in the control group after treatment, the differences were highly statistically significant (all P ＜ 0.01). Conclusion Hyaluronic acid repair biofilm combined with Loratadine Tablets can significantly improve the clinical symptoms, skin barrier function and clinical efficacy of atopic dermatitis patients, and its possible mechanism is related to the regulation of Th1/Th2 cytokine balance.
2020, Vol. 17 
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