川芎嗪对血管内皮损伤的保护作用机制研究进展

摘要
图/表
参考文献(33)
相关文章 (15)

全文: PDF (577 KB) HTML (1 KB)
输出: BibTeX | EndNote (RIS)

摘要血管内皮的受损程度与高血压等心血管疾病的发展进程密切相关。高血压、冠心病以及动脉粥样硬化等多种心血管疾病均会出现不同程度的血管内皮损伤，保护损伤的内皮细胞是心血管疾病防治的关键。川芎嗪是从中草药川芎中提取的一种生物碱，具有生物活性和多种药理作用。其药理作用包括延缓内皮细胞凋亡、促进血管新生、抗炎、抗氧化等，可用于治疗高血压病引起的血管结构和功能的改变。本文综述了川芎嗪抗高血压病血管内皮损伤的作用机制及其研究进展，为川芎嗪治疗心脑血管病的临床应用提供科学依据。

	服务

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章
	李芳芳张琪

关键词 ：川芎嗪, 血管内皮损伤, 血管新生, 氧化应激

Abstract：The degree of vascular endothelial injury is closely related to the development of cardiovascular diseases such as hypertension. Many kinds of cardiovascular diseases, such as hypertension, coronary heart disease and atherosclerosis, will present different degrees of vascular endothelial injury, and the protection of injured endothelial cells is the key to the prevention and treatment of cardiovascular diseases. Tetramethylpyrazine is a kind of alkaloid extracted from Chinese herbal medicine Ligusticum chuanxiong Hort.. It has biological activity and many pharmacological effects. Its pharmacological effects include, delaying endothelial cell apoptosis, promoting angiogenesis, anti-inflammatory, antioxidant, etc. It can be used to treat the changes in vascular structure and function caused by hypertension. This article reviews the research progress of Tetramethylpyrazine against vascular endothelial injury in hypertension, and provides scientific basis for the clinical application of Tetramethylpyrazine in the treatment of cardiovascular and cerebrovascular diseases.

Key words： Tetramethylpyrazine Vascular endothelial injury Angiogenesis Oxidative stress

基金资助:国家自然科学基金资助项目（81470543、817742 95）。

通讯作者: 张琪（1977-），男，博士，教授，硕士生导师，主要从事心血管疾病的中西医结合防治研究工作。

作者简介: 李芳芳（1991-），女，陕西中医药大学基础医学院2018级中西医结合基础专业在读硕士研究生，主要从事心血管疾病的中西医结合防治研究工作。

引用本文:

李芳芳张琪. 川芎嗪对血管内皮损伤的保护作用机制研究进展[J]. 中国医药导报, 2020, 17(8): 25-28.
LI Fangfang ZHANG Qi. Advance in studies on the protective effect of Tetramethylpyrazine on vascular endothelial injury. 中国医药导报, 2020, 17(8): 25-28.

链接本文:

http://www.yiyaodaobao.com.cn/CN/ 或 http://www.yiyaodaobao.com.cn/CN/Y2020/V17/I8/25

[1] 杨敏，李慧，朱博文，等.川芎嗪抑制血管重塑的研究进展[J].中国中西医结合杂志，2018，38（3）：379-383.
[2] 李萍.血管内皮细胞病理生理作用的研究进展[J].微循环学杂志，2014，24（4）：1-7.
[3] Guo M，Liu Y，Shi D，et al. Cardiovascular Actions and Therapeutic Potential of Tetramethylpyrazine （Active Component Isolated from Rhizoma Chuanxiong）：Roles and Mechanisms [J]. Biomed Res Int，2016，2016（2016）：2430329.
[4] 蒋跃绒，陈可冀.川芎嗪的心脑血管药理作用及临床应用研究进展[J].中国中西医结合杂志，2013，33（5）：707-711.
[5] 马玉，马先林.川芎嗪对心血管的药理作用、临床应用及其效果分析[J].世界最新医学信息文摘，2019，19（30）：213-219.
[6] Smiljic S. The clinical significance of endocardial endothelial dysfunction [J]. Medicina （Kaunas），2017，53（5）：295-302.
[7] Feng EZ，Yang SY，Huang NX，et al. Plasma endothelin-1 and nitric oxide correlate with ligustrazine alleviation of pulmonary artery hypertension in patients of chronic cor pulmonale from high altitude plateau during acute exacerbation [J]. Zhongguo Ying Yong Sheng Li Xue Za Zhi，2014， 30（6）：532-537.
[8] 张国平，孙梅，杨洁红，等.川芎嗪对缺氧人脐静脉内皮细胞抗凝和纤溶功能的影响[J].中草药，2008，39（1）：71-73.
[9] Li H，Yang X，Shi W，et al. Protective Effects of Tetramethylpyrazine on Cerebrovascular Regulations in Rats with Chronic Alcoholic Encephalopathy [J]. Biomed Environ Sci，2015，28（9）：691-695.
[10] 方浩.川芎嗪对妊娠高血压疾病患者血管内皮细胞功能和肾功能的影响[J].中国药师，2010，13（3）：403-404.
[11] 陈秋芳，朱晓峰，韩莉，等.丹参川芎嗪注射液治疗不稳定型心绞痛的Meta分析[J].中成药，2016，38（2）：272-277.
[12] Gao K，Shen Z，Yuan Y，et al. Simvastatin inhibits neural cell apoptosis and promotes locomotor recovery via activation of Wnt/beta-catenin signaling pathway after spinal cord injury [J]. J Neurochem，2016，138（1）：139-149.
[13] Hu JZ，Wang XK，Cao Y，et al. Tetramethylpyrazine Facilitates Functional Recovery after Spinal Cord Injury by Inhibiting MMP2，MMP9，and Vascular Endothelial Cell Apoptosis [J]. Curr Neurovasc Res，2017，14（2）：110-116.
[14] Qing L，Wu P，Zhou Z，et al. Tetramethylpyrazine improved the survival of multiterritory perforator flaps by inducing angiogenesis and suppressing apoptosis via the Akt/Nrf2 pathway [J]. Drug Des Devel Ther，2019，13：1437-1447.
[15] Yang C，Xu Y，Zhou H，et al. Tetramethylpyrazine protects CoCl2-induced apoptosis in human umbilical vein endothelial cells by regulating the PHD2/HIF/1α-VEGF pathway [J]. Mol Med Rep，2016，13（2）：1287-1296.
[16] Chandra J，Samali A，Orrenius S. Triggering and modulation of apoptosis by oxidative stress[J]. Free Radic Biol Med，2000，29（3/4）：323-333.
[17] Yang G，Qian C，Wang N，et al. Tetramethylpyrazine Protects Against Oxygen-Glucose Deprivation-Induced Brain Microvascular Endothelial Cells Injury via Rho/Rho-kinase Signaling Pathway [J]. Cell Mol Neurobiol，2017，37（4）：619-633.
[18] Cheng XR，Zhang L，Hu JJ，et al. “Neuroprotective effects of tetramethylpyrazine on hydrogen peroxide-induced apoptosis in PC12 cells” [J]. Cell Biol Int，2007，31（5）：438-443.
[19] Li WM，Liu HT，Li XY，et al. The Effect of Tetramethylpyrazine on Hydrogen Peroxide-Induced Oxidative Damage in Human Umbilical Vein Endothelial Cells [J]. Basic Clin Pharmacol Toxicol，2010，106（1）：45-52.
[20] 周沐科，何俐，吴波，等.大川芎丸对血管内皮细胞中血管内皮生长因子分泌水平的影响[J].中国临床康复，2004，8（19）：3842-3843，3918.
[21] Yuan R，Shi WL，Xin QQ，et al. Tetramethylpyrazine and Paeoniflorin Inhibit Oxidized LDL-Induced Angiogenesis in Human Umbilical Vein Endothelial Cells via VEGF and Notch Pathways [J]. Evid Based Complement Alternat Med，2018，2018：3082507.
[22] Jiang Yn，Liu C，Chen WH，et al. Tetramethylpyrazine enhances vascularization and prevents osteonecrosis in steroid-treated rats [J]. Bio Med Res Int，2015，315850：1-12.
[23] Hong M，Shi H，Wang N，et al. Dual Effects of Chinese Herbal Medicines on Angiogenesis in Cancer and Ischemic Stroke Treatments：Role of HIF-1 Network [J]. Front Pharmacol，2019，10（696）：1-17.
[24] Mehmood K，Zhang H，Li K，et al. Effect of tetramethylpyrazine on tibial dyschondroplasia incidence，tibial angiogenesis，performance and characteristics via HIF-1α/VEGF signaling pathway in chickens [J]. Sci Rep，2018，8（2495）：1-10.
[25] Liang X，Zhou H，Ding Y，et al. TMP Prevents Retinal Neovascularization and Imparts Neuroprotection in an Oxygen-Induced Retinopathy Model [J]. Invest Ophthalmol Vis Sci，2012，53（4）：2157-2169.
[26] Wang Y，Zhu H，Tong J，et al. Ligustrazine improves blood circulation by suppressing Platelet activation in a rat model of allergic asthma [J]. Environ Toxicol Pharmacol，2016，45：334-339.
[27] Zhu X，Wang K，Zhang K，et al. Tetramethylpyrazine Protects Retinal Capillary Endothelial Cells（TR-iBRB2） against IL-1β-Induced Nitrative/Oxidative Stress [J]. Int J Mol Sci，2015，16（9）：21775-21790.
[28] Sun MY，Zhang M，Chen SL，et al. The Influence of Hyperlipidemia on Endothelial Function of FPN1 Tek-Cre Mice and the Intervention Effect of Tetramethylpyrazine [J]. Cell Physiol Biochem，2018，47（1）：119-128.
[29] Wu X，Zhang F，Xiong X，et al. Tetramethylpyrazine Reduces Inflammation in Liver Fibrosis and Inhibits Inflammatory Cytokine Expression in Hepatic Stellate Cells by Modulating NLRP3 Inflammasome Pathway [J]. IUBMB Life，2015，67（4）：312-321.
[30] Chen AF，Chen DD，Daiber A，et al. Free radical biology of the cardiovascular system [J]. Clin Sci（Lond），2012， 123（2）：73-91.
[31] Salisbury D，Bronas U. Reactive oxygen and nitrogen species：impact on endothelial dysfunction [J]. Nurs Res，2015，64（1）：53-66.
[32] Bedard K，Krause KH. The NOX family of ROS-generating NADPH oxidases：physiology and pathophysiology [J]. Physiol Rev，2007，87（1）：245-313.
[33] Ni Xj，Wong SL，Wong CM，et al. Tetramethylpyrazine Protects against Hydrogen Peroxide-Provoked Endothelial Dysfunction in Isolated Rat Aortic Rings：Implications for Antioxidant Therapy of Vascular Diseases [J]. Evid Based Complement Alternat Med，2014，2014（2）：627181.