输血对胃癌手术患者预后影响的meta分析

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摘要目的评价围术期外源性输血（ABT）对胃癌手术患者预后的影响。方法计算机检索PubMed、Cochrane Library、EMBASE、Highwire生物医学数据库，收集2000年1月～2019年1月研究围术期ABT对胃癌手术患者预后影响的临床对照试验。采用Stata 12.0版本软件进行meta分析，系统评价围术期ABT对5年生存率、肿瘤复发率、术后并发症发生率的影响。结果共纳入20篇高质量相关文献。与非输血组比较，ABT组患者5年生存率降低（OR = 0.47，95%CI：0.39～0.56，P = 0.005），肿瘤复发率（OR = 2.09，95%CI：1.35～3.25，P = 0.000）和术后并发症发生率升高（OR = 2.40，95%CI：1.81～3.19，P = 0.000），差异有统计学意义。结论围术期ABT对胃癌手术患者预后产生不良影响。

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	古力帕日·克力木张蕾▲

关键词 ：外源性输血, 胃癌手术, 5年生存率, 肿瘤复发, 术后并发症

Abstract：Objective To evaluate affects about perioperative allogenenic blood transfusion (ABT) on the prognosis of patients with gastric cancer surgery. Methods PubMed, Cochrane Library, EMBASE, and Highwire biomedical databases were retrieved by computer, and clinical controlled trials from January 2000 to January 2019 to study the effect of perioperative ABT on the prognosis of patients with gastric cancer surgery were collected. A meta-analysis was performed using Stata version 12.0 software to systematically evaluate the effects of perioperative ABT on 5-year survival, tumor recurrence, and postoperative complications. Results A total of 20 high-quality related literatures were included. Compared with the non-transfusion group, the 5-year survival rate of patients in the ABT group was reduced (OR = 0.47, 95%CI: 0.39-0.56, P = 0.005), while the tumor recurrence rates (OR = 2.09, 95%CI: 1.35-3.25, P = 0.000) and the incidence of postoperative complications were increased (OR = 2.40, 95%CI: 1.81-3.19, P = 0.000), and the differences were statistically significant. Conclusion Perioperative ABT can adversely affect the prognosis of patients with gastric cancer surgery.

Key words： Allogenenic blood transfusion Gastrointestinal cancer surgery Five-year survival rate Tumor recurrence rate Postoperative complication rate

基金资助:新疆医科大学第一附属医院院内自然科学基金-青年基金项目（2015ZRQN12）。

通讯作者: ▲通讯作者

作者简介: 古力帕日·克力木（1983.1-），女，硕士；研究方向：围术期输血保护、体温保护。

引用本文:

古力帕日·克力木张蕾▲. 输血对胃癌手术患者预后影响的meta分析[J]. 中国医药导报, 2020, 17(7): 98-101,105.
KELIMU·Gulipari1 ZHANG Lei▲. A meta-analysis of the effects of blood transfusion on the prognosis of patients undergoing gastric cancer surgery. 中国医药导报, 2020, 17(7): 98-101,105.

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http://www.yiyaodaobao.com.cn/CN/ 或 http://www.yiyaodaobao.com.cn/CN/Y2020/V17/I7/98

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