Correlation analysis between NF-κBIA gene polymorphism and neonatal bacterial meningitis susceptibility
LI Wenjuan MEI Jiaping YANG Yong YE Sufen
Department of Neonatology, Affiliated Shenzhen Maternity & Child Healthcare Hospital, Southern Medical University, Guangdong Province, Shenzhen 518028, China
Abstract：Objective To investigate the relationship between NF-κBIA gene polymorphism and neonatal bacterial meningitis susceptibility. Methods From March 2016 to March 2019, 211 cases admitted to the Department of Neonatology, Affiliated Shenzhen Maternity & Child Healthcare Hospital, Southern Medical University. Among them, 67 cases of neonatal meningitis were in the case group, 69 normal neonates were in the control group, and 75 cases with non-meningitis inflammatory febrile neonates were in the fever group. Two SNP sites (rs3138053 and rs2233406) of NF-κBIA gene were genotyped by PCR amplification using Sanger sequencing. The genotype sequencing results of different sites and the susceptibility analysis of neonates bacterial meningitis were observed. Results rs3138053 and rs2233406 were in good agreement with the expected value and the observed value in three groups, which were consistent with Hardy-Weinberg equilibrium (P > 0.05). rs3138053 was correlated with the susceptibility of neonatal bacterial meningitis (P < 0.05). Conclusion NF-κBIA gene polymorphism is associated with susceptibility to neonatal bacterial meningitis.
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