The value of dynamic monitoring of plasma (1,3)-beta-D-glucan content in evaluating the efficacy of drugs in patients with invasive fungal infection
WEN Donghua1 LIU Yuhua1▲ TAN Jian2 HUANG Changjian3 LI Jun1
1.Department of Pharmacy, the People′s Hospital of Wuzhou, Guangxi Zhuang Autonomous Region, Wuzhou 543000, China;
2.Department of Clinical Laboratory, the People′s Hospital of Wuzhou, Guangxi Zhuang Autonomous Region, Wuzhou 543000, China;
3.Department of Neurosurgery, the People′s Hospital of Wuzhou, Guangxi Zhuang Autonomous Region, Wuzhou 543000, China
Abstract:Objective To investigate the value of (1,3)-beta-D-glucan dynamic detection in evaluating the efficacy of antifungal drugs in invasive fungal infections. Methods The levels of (1,3)-beta-D-glucan from 42 patients with invasive fungal infections were detected by fungi (1,3)-beta-D-beta-glucan assay kit, who were treated in the People′s Hospital of Wuzhou from March 2013 to March 2017, with analyzing the clinical data of the cases. Results After antifungal treatment, the levels of plasma (1, 3)-beta-D-dextran were significantly reduced in 40 patients, of which the levels of 5 patients decreased to normal levels after a small increase. Besides, the levels of 2 patients were not decreased to normal levels. Conclusion Dynamic detection of plasma (1,3)-beta-D-glucan in patients with invasive fungal infection is an effective indicator to evaluate the efficacy of antifungal drugs, which can guide the rational use of antifungal drugs in clinic.
温冬华1 刘钰华1▲ 谭坚2 黄常坚3 李军1 . 动态监测血浆(1,3)-β-D-葡聚糖含量对评价侵袭性真菌感染患者药物疗效的价值[J]. 中国医药导报, 2017, 14(35): 110-113,117.
WEN Donghua1 LIU Yuhua1▲ TAN Jian2 HUANG Changjian3 LI Jun1. The value of dynamic monitoring of plasma (1,3)-beta-D-glucan content in evaluating the efficacy of drugs in patients with invasive fungal infection. 中国医药导报, 2017, 14(35): 110-113,117.