Abstract：Objective To investigate the safety and efficacy of Gangshu Lotion in rehabilitation of mixed hemorrhoid after operation, to observe its influence on the change of prostaglandin E2 (PGE2) content in serum, in order to clarify its possible analgesic mechanism. Methods Sixty patients with mixed hemorrhoid admitted to Affiliated Hospital of Zunyi Medical College from January to July in 2017 were selected and divided into Chinese medicine group and western medicine group by random number table, with 30 cases in each group. Both groups were treated by Milligan-Morgan operation. After operation, the Chinese medicine group was treated by fumigation and sitz bath with self-made Gangshu Lotion. After operation, the western medicine group was treated by fumigation and sitz bath with povidone, both treatment until the wounds healed. All patients were assessed about wound pain, edema, hemafecia at 1 day, 3 days, 5 days after operation, and the levels of serum PGE2 were measured by enzyme-linked immunosorbent assay. Results The regression time of edema and wound healing of the Chinese medicine group were shorter than those of the western medicine group, with statistically significant difference (P < 0.05). 5 days after operation, the bleeding score of the Chinese medicine group was lower than that of the western medicine group, with statistically significant difference (P < 0.05). The scores of pain and the levels of PGE2 in the two groups at 3 days and 5 days after operation were significantly higher than those at 1 day after operation, and those of the Chinese medicine group were lower than those of the western medicine group, with statistically significant difference (P < 0.05). Conclusion Gangshu Lotion can effectively improve rehabilitation of mixed hemorrhoid after operation. The analgesic mechanism may be related to the decrease of the levels of serum PGE2.
2017, Vol. 14 
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