李延教授运用化瘀祛痰汤治疗顽固性失眠的效果及对血清细胞因子的影响

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摘要目的探讨李延教授运用化瘀祛痰汤治疗顽固性失眠的临床效果及对血清细胞因子的影响。方法选取2018年10月～2019年9月在李延名医工作室门诊就诊的60例顽固性失眠患者，采用随机数字表法将其分为对照组和治疗组，各30例。对照组给予艾司唑仑片治疗，治疗组在对照组的基础上给予化瘀祛痰汤治疗。10 d为1个疗程，共3个疗程。比较两组治疗前后中医证候评分及匹兹堡睡眠质量指数（PSQI）评分，观察两组临床疗效及治疗前后血清细胞因子水平变化情况，并记录不良反应发生情况。结果两组治疗后中医证候总积分及PSQI总评分均明显低于治疗前（P ＜ 0.05），且治疗组治疗后的中医证候总积分及PSQI总评分均明显低于对照组（P ＜ 0.05）。治疗组临床疗效优于对照组，差异有统计学意义（P ＜ 0.05）。两组治疗后血清白介素（IL）-1β、肿瘤坏死因子α（TNF-α）及IL-6水平均明显低于治疗前（P ＜ 0.05），且治疗组治疗后血清IL-1β、TNF-α及IL-6水平均明显低于对照组（P ＜ 0.05）。两组总不良反应发生率比较差异无统计学意义（P ＞ 0.05）。结论化瘀祛痰汤治疗顽固性失眠患者可明显改善临床症状及睡眠质量，提高治疗效果，降低血清IL-1β、TNF-α及IL-6水平，且安全性较好，具有推广应用价值。

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	王琪1 李延2 李勇3 吴限4▲

关键词 ：化瘀祛痰汤, 顽固性失眠, 临床效果, 睡眠质量, 血清细胞因子

Abstract：Objective To explore the clinical effect of Huayu Qutan Decoction in the treatment of intractable insomnia by professor Li Yan and its influence on serum cytokines. Methods From October 2018 to October 2019, 60 patients with intractable insomnia treated in Outpatient Department of LI Yan Famous Doctor Studio were selected and randomly divided into control group and treatment group, with 30 cases in each group. The control group was treated with Estazolam Tablets, while the treatment group was treated with Huayu Qutan Decoction on the basis of the control group. The two groups were treated for 3 courses (10 days as one course). The scores of TCM syndromes and Pittsburgh sleep quality index (PSQI) before and after treatment were compared between the two groups. The clinical efficacy and changes of serum cytokine levels in the two groups were observed before and after treatment. The occurrence of adverse reactions was recorded. Results The total scores of TCM syndromes and PSQI in the two groups after treatment were significantly lower than those before treatment (P ＜ 0.05), and the total scores of TCM syndromes and PSQI in the treatment group were significantly lower than those in the control group after treatment (P ＜ 0.05). The clinical efficacy of treatment group was better than that of control group, the dfference was statistically significant (P ＜ 0.05). After treatment, the serum levels of interleukin (IL)-1β, tumor necrosis factor α (TNF-α) and IL-6 in the two groups were significantly lower than those before treatment (P ＜ 0.05), and the serum levels of IL-1β, TNF-α and IL-6 in the treatment group were significantly lower than those in the control group after treatment (P ＜ 0.05). There was no significant difference in the incidence of total adverse reactions between the two groups (P ＞ 0.05). Conclusion Huayu Qutan Decoction can significantly improve the clinical symptoms and sleep quality of patients, enhance the therapeutic effect, reduce the levels of serum IL-1β, TNF-α and IL-6, and it is safe and has the value of promotion and application.

Key words： Huayu Qutan Decoction Refractory insomnia Clinical effect Sleep quality Serum cytokines

基金资助:黑龙江省中医药科研项目（ZHY18-040）。

通讯作者: ▲通讯作者

作者简介: 王琪（1982.11-），女，硕士；研究方向：心脑血管疾病。

引用本文:

王琪1 李延2 李勇3 吴限4▲. 李延教授运用化瘀祛痰汤治疗顽固性失眠的效果及对血清细胞因子的影响[J]. 中国医药导报, 2020, 17(3): 119-122.
WANG Qi1 LI Yan2 LI Yong3 WU Xian4▲. Effect of Huayu Qutan Decoction in the treatment of intractable insomnia by professor Li Yan and its influence on serum cytokines. 中国医药导报, 2020, 17(3): 119-122.

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http://www.yiyaodaobao.com.cn/CN/ 或 http://www.yiyaodaobao.com.cn/CN/Y2020/V17/I3/119

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