瞬时受体电位通道在下尿路中的表达与功能的相关综述

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摘要瞬时受体电位超家族中一些通道在下尿路中广泛表达，如TRPV1、TRPV4、TRPA1、TRPM4和TRPM8通道。这些瞬时受体电位通道参与了下尿路中诸多生理及病理活动，与一些下尿路功能障碍疾病、膀胱癌和前列腺癌的发病机制有关，如TRPV1通道与膀胱过度活动症，TRPV4、TRPA1和TRPM4通道与逼尿肌过度活动，TRPM4、TRPM8通道与前列腺癌。瞬时受体电位通道可作为这些疾病临床治疗的新靶点，如TRPV1通道激动剂辣椒辣素已用于膀胱过度活动症的临床治疗中，不过这一目标仍需要后续大量的研究而获得实现。

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	任杰1 高宏飞2

关键词 ：下尿路, 膀胱过度活动症, 前列腺癌, TRPV1通道, TRPM8通道

Abstract：Some channels in the transient receptor potential superfamily are widely expressed in the lower urinary tract, such as TRPV1, TRPV4, TRPA1, TRPM4 and TRPM8 channels. These transient receptor potential channels participate in many physiological and pathological activities in the lower urinary tract. It is related to the pathogenesis of lower urinary tract dysfunction, bladder cancer and prostate cancer. For example, TRPV1 channel and overactivity of bladder, TRPV4, TRPA1 and TRPM4 channel with overactivity of detrusor, TRPM4 channel and TRPM8 channel with prostate cancer. Transient receptor potential channel can be used as a new target for clinical treatment of these diseases. For example, the TRPV1 channel agonist capsaicin has been used in the clinical treatment of overactive bladder, but this goal still needs to be achieved through follow-up studies.

Key words： Lower urinary tract Overactive bladder Prostate cancer TRPV1 channel TRPM8 channel

基金资助:山西省留学回国人员科技活动择优资助项目（晋人社厅函[2017]397号）。

通讯作者: 高宏飞（1975.6-），男，博士，副教授，副主任医师；研究方向：尿动力学。

作者简介: 任杰（1995.3-），男，山西医科大学第一临床医学院2017级泌尿外科专业在读硕士研究生；研究方向：尿动力学。

引用本文:

任杰1 高宏飞2. 瞬时受体电位通道在下尿路中的表达与功能的相关综述[J]. 中国医药导报, 2020, 17(3): 45-48.
REN Jie1 GAO Hongfei2. Review on relationship between the expression and function of transient receptor potential channels in the lower urinary tract. 中国医药导报, 2020, 17(3): 45-48.

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http://www.yiyaodaobao.com.cn/CN/ 或 http://www.yiyaodaobao.com.cn/CN/Y2020/V17/I3/45

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