Correlation analysis on the expression of serum IL-8, Fractalkine, MIP-3α and clinical features of lung cancer in patients with newly diagnosed lung cancer
WANG Gang LYU Jinyan WANG Ruoyu ZHAO Jing LIU Ying TANG Rongbin
The First Department of Oncology, Zhongshan Hospital Affiliated to Dalian University, Liaoning Province, Dalian 116001, China
Abstract:Objective To analyze the correlation of the expression of serum interleukin-8 (IL-8), chemotactic factor (Fractalkine), macrophage inflammatory protein-3α (MIP-3α) and clinical features of lung cancer in patients with newly diagnosed lung cancer. Methods The clinical data of 90 patients with newly diagnosed lung cancer (newly diagnosed lung cancer group, 21 cases of small cell carcinoma and 69 cases of non small cell carcinoma) admitted to Zhongshan Hospital Affiliated to Dalian University from January 2013 to December 2015 and 90 healthy controls with normal results of outpatient physical examination at the same time (healthy group) was analyzed retrospectively. Firstly, the levels of serum IL-8, Fractalkine, MIP-3α between newly diagnosed lung cancer group and healthy group were compared. Secondly, the newly diagnosed lung cancer group was divided into different groups according to Ⅰ+Ⅱ stage and Ⅲ+Ⅳ stage, small cell carcinoma and non-small cell carcinoma, and the levels of serum IL-8, Fractalkine and MIP-3 were compared. At last, Pearson correlation test was used to analyze the relationship among the levels of serum IL-8, Fractalkine and MIP-3 in newly diagnosed lung cancer group. Results ①The levels of IL-8, Fractalkine, MIP-3α in newly diagnosed lung cancer group were higher than those in healthy group (P < 0.01). ②The levels of IL-8, Fractalkine, MIP-3α in Ⅰ+Ⅱ stage group were lower than those in Ⅲ+Ⅳ stage group (P < 0.01). ③The levels of IL-8, Fractalkine, MIP-3α in small cell carcinoma group were higher than those in non-metastasis group, but the differences were not statistically significant (P > 0.05). ④Pearson correlation analysis showed that there was linear correlation of IL-8 and Fractalkine (r = 0.598, P < 0.05), IL-8 and MIP-3α (r = 0.641, P < 0.05), Fractalkine and MIP-3α (r = 0.682, P < 0.05). Conclusion The levels of IL-8, Fractalkine, MIP-3α in patients with newly diagnosed lung cancer are higher than those of healthy persons, and increase with the escalation of the disease, but there are no significant differences between different pathological types. Three indicators are linearly related to each other and can be used for the condition judgment of patients with newly diagnosed lung cancer.
王刚 吕金燕 王若雨 赵婧 刘莹 唐荣彬. 初诊肺癌患者血清IL-8、Fractalkine、MIP-3α表达与肺癌临床特征的相关性分析[J]. 中国医药导报, 2017, 14(35): 92-95.
WANG Gang LYU Jinyan WANG Ruoyu ZHAO Jing LIU Ying TANG Rongbin. Correlation analysis on the expression of serum IL-8, Fractalkine, MIP-3α and clinical features of lung cancer in patients with newly diagnosed lung cancer. 中国医药导报, 2017, 14(35): 92-95.
[1] 钱桂生,余时沧.肺癌流行病学最新资料与启示[J].中华结核和呼吸杂志,2012,35(2):3-6.
[2] Gutschner T,Hämmerle M,Eissmann M,et al. The noncoding RNA MALAT1 is a critical regulator of the metastasis phenotype of lung cancer cells [J]. Cancer Res,2013,73(3):1180-1189.
[3] 吴凤英,周彩存.趋化因子与肺癌[J].国际肿瘤学杂志,2011,38(4):275-277.
[4] 张霄鹏,胡志娟,孟爱宏,等.血清趋化因子CCL20与非小细胞肺癌胸腔镜根治术后早期复发及转移的关系[J].广东医学,2015,36(23):3679-3682.
[5] 支修益,吴一龙,马胜林,等.原发性肺癌诊疗规范(2011年版)[J].中国肺癌杂志,2012,15(12):677-688.
[6] Hou JM,Krebs M,Ward T,et al. Circulating tumor cells as a window on metastasis biology in lung cancer [J]. Am J Pathol,2011,178(3):989-996.
[7] 李国栋,欧阳伟炜,苏胜发,等.趋化因子与肺癌[J].国际肿瘤学杂志,2016,43(10):103-105.
[8] Mentlein R,Hattermann K,Held-Feindt J. Migration,metastasis,and more:The role of chemokines in the proliferation,spreading,and metastasis of tumors [M]. Trends in Stem Cell Proliferation and Cancer Research. Netherlands:Springer,2013:339-358.
[9] 王菀菀,孙俊宁,操珍,等.肺癌患者血清趋化因子的表达水平及临床意义[J].国际肿瘤学杂志,2016,43(2):215-218.
[10] Nwajei F,Becerenbraun F,Gabrusiewicz K,et al. Organ specificity of cancer metastasis depends on the adaptive immune surveillance and the neuronal chemokine fractalkine(TUM10P.1030)[J]. J Immunol,2015,194(1):211.
[11] 曹宝森,李霞,常茂叶,等.外周血IL-8和Fractalkine表达与非小细胞肺癌病理特征的关系[J].河北医科大学学报,2013,34(7):757-760.
[12] 马钟铃,秦思达,张伯翔,等.非小细胞肺癌中IL-8与MCP-1的表达及其临床意义[J].现代肿瘤医学,2016, 24(3):394-397.
[13] 张付美,李磊,牛慧君,等. Survivin mRNA和血清IL-8表达水平在大鼠肺鳞癌中的相关性研究[J].中国实用医刊,2015,42(17):64-67.
[14] Yadav A,Kumar B,Teknos TN,et al. Abstract 3431:Role of tumor microenvironment in promoting tumor metastasis [J]. Cancer Research,2011,70(8 Suppl):3431-3432.
[15] Zuccari DA,Leonel C,Castro R,et al. An immunohistochemical study of interleukin-8(IL-8)in breast cancer [J]. Acta Histochem,2012,114(6):571-576.
[16] Desai S,Laskar S,Pandey BN. Autocrine IL-8 and VEGF mediate epithelial-mesenchymal transition and invasiveness via p38/JNK-ATF-2 signalling in A549 lung cancer cells [J]. Cell Signal,2013,25(9):1780-1791.
[17] 董瑛,施英,沈建平,等.香菇多糖联合GP化疗方案治疗晚期非小细胞肺癌近期疗效及对外周血促炎性细胞因子IL-1β、IL-6和TNF-α表达的影响[J].中国现代医生,2017,55(3):18-21.
[18] 黄李雅,陈平,张树贤,等.干扰趋化因子Fractalkine的表达对胰腺癌细胞株生物学功能的影响[J].中华消化杂志,2012,32(9):215-218.
[19] Iwata T,Tanaka K,Inoue Y,et al. Macrophage inflammatory protein-3 alpha(MIP-3a)is a novel serum prognostic marker in patients with colorectal cancer [J]. J Surg Oncol,2013,107(2):160-166.
[20] 汪珺,苏晓三,乔飞,等.肺癌围手术期髓系抑制细胞的变化及对肿瘤生长和血管生成的影响[J].肿瘤,2016, 36(4):452-458.