Correlation between serum hepatitis C virus RNA titers and liver fibrosis in chronic Hepatitis C virus patients
SHAO Linnan1* ZHANG Shuting1* ZHOU Shihang1 WANG Ni1 PAN Lingzi1▲ LIU Ming2▲
1.Dalian Blood Center, Liaoning Province, Dalian 116001, China;
2.Department of Cell Biology, Dalian Medical University, Liaoning Province, Dalian 116044, China
Abstract：Objective To investigate the relationship between serum hepatitis C virus (HCV) and liver fibrosis in patients with chronic HCV infection. Methods A total of 162 chronic HCV patients without other liver or major diseases admitted to the Dalian Sixth People′s Hospital from April to December 2015 were selected. The association between HCV ribonucleic acid (RNA) titers and liver fibrosis was studied by using serum collagen Ⅳ (C-Ⅳ), laminin (LN), Type-Ⅲ pro-collagen (PⅢNP), hyaluronic acid (HA) and FibroScan transient elasticity. In order to further assess the correlation between HCV RNA titers and liver fibrosis, chronic HCV patients were divided into three groups according to the results of lg-transformed HCV RNA titers: lg(HCV RNA) ≤5 group, 5＜lg(HCV RNA) ≤7 group and lg(HCV RNA) ＞7 group. Four serum indices of liver fibrosis were collected from 162 patients, of which only 54 patients were tested for FibroScan transient elasticity. The serum HCV RNA titers were automatically calculated by the instrument software and used for the 10-base logarithmic representation. Results Among 162 patients with chronic HCV, there were no statistically significant differences in hepatic fibrosis among different viral load groups (P ＞ 0.05). There was no statistically significant difference in Fibroscan among 54 patients with chronic HCV in different viral load groups (P ＞ 0.05). FibroScan transient elasticity was correlated with C-Ⅳ, LN, PⅢNP and HA (r = 0.530, 0.340, 0.289, 0.438, P = 0.000, 0.007, 0.023, 0.000). The HCV RNA titers were not correlated with four serum indices of liver fibrosis (P ＞ 0.05). Conclusion Serum HCV RNA titers in patients with chronic HCV are not correlated with C-Ⅳ, LN, PⅢNP, HA and FibroScan transient elasticity, serum HCV RNA viral titers can not reflect the degree of liver fibrosis.
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2020, Vol. 17 
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