1.Department of Pediatrics, Changxing People′s Hospital of Zhejiang Province (Changxing Hospital, the Second Affiliated Hospital of Zhejiang University Medical College), Zhejiang Province, Changxing 313100, China;
2.Department of Clinical Laboratory, Changxing People′s Hospital of Zhejiang Province (Changxing Hospital, the Second Affiliated Hospital of Zhejiang University Medical College), Zhejiang Province, Changxing 313100, China;
3.Deparement of Clinical Laboratory, the First Affiliated Hospital of Wannan Medical College of Anhui Province, Anhui Province, Wannan 241001, China
Abstract：Objective To investigate the effect of Levetiracetam on children with febrile seizure (FS) and its effect on the expression of neuron-specific enolase (NSE) and S-100 Mongolian protein (S-100β) in serum. Methods From November 2017 to April 2019, 70 children with FS in Department of Pediatrics, Changxing People′s Hospital of Zhejiang Province were selected as the study objects, According to the random number table method, the patients were divided into control group and observation group, 35 cases in each group. The control group was treated with oral Diazepam Tablets, while the observation group was treated with oral Levetiracetam Tablets. The course of treatment was set as 3 d. After one course of treatment, the patients were followed up for 6 months to 1 year. The recurrence rate of convulsion and incidence of adverse reactions were compared between the two groups. NSE and S-100 were measured before and after treatment. Results During the study and follow-up, 5 patients in the control group dropped out due to active withdrawal, poor compliance and follow-up release, while 3 patients in the observation group dropped out. In order to maintain the quantity balance, 30 patients were eventually included in each group. Follow-up for 6 months to 1 year showed no statistically significant difference in the recurrence rate of convulsion between the two groups (P ＞ 0.05). The incidence of adverse reactions in the observation group was lower than that in the control group, and the difference was statistically significant (P ＜ 0.05). Before treatment, there was no significant difference in NSE and S-100 between the two groups (P ＞ 0.05). NSE and S-100 in both groups were lower than those before treatment, and NSE and S-100 in the observation group were lower than those in the control group, with statistically significant differences (all P ＜ 0.05). Conclusion Levetiracetam can effectively prevent FS recurrence, and its relapse prevention effect is equivalent to that of Diazepam. With high clinical safety and less adverse reactions, it can effectively improve the level of cerebral nerve factors NSE and S-100 in children with FS, and has a good effect on brain protection.
丁鸿飞1 朱香兰1 章笑安1 王叶萍2 陈 鹏3 董灵1 卓超1. 左乙拉西坦治疗小儿热性惊厥的效果及对血清神经元特异性烯醇化酶、S-100β蛋白表达的影响[J]. 中国医药导报, 2019, 16(36): 119-122.
DING Hongfei1 ZHU Xianglan1 ZHANG Xiao′an1 WANG Yeping2 CHEN Peng3 DONG Ling3 ZHUO Chao1. Effect of Levetiracetam on children with febrile seizure and its effect on expression of neuron-specific enolase and S-100β protein in serum. 中国医药导报, 2019, 16(36): 119-122.
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2019, Vol. 16 
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