Cognition investigation of GnRH-a in combination with add-back therapy in ethnic minority patients with uterine leiomyoma in Xinjiang District and discussion the new model of health education
ZHU Ye1 MI Juanni2 ZHU Hongyan1▲ HE Yan1
1.Ward 3, Department of Gynecology, the First Affiliated Hospital of Xinjiang Medical University, Xinjiang Uygur Autonomous Region, Urumqi 830054, China; 2.VIP of Internal Medicine, the First Affiliated Hospital of Xinjiang Medical University,Xinjiang Uygur Autonomous Region, Urumqi 830054, China
Abstract:Objective To survey cognition level of gonadotrophin releasing hormone agonist (GnRH-a) in combination with add-back therapy in ethnic minority patients with uterine leiomyoma in Xinjiang District and discuss the new model of health education. Methods From January 2017 to December 2018, 80 ethnic minority cases with uterine leiomyoma received GnRH-a combination with add-back therapy in the First Affiliated Hospital of Xinjiang Medical University were collected as observational objects. According to the random number table method, they were divided into control group and observation group, with 40 cases in each group. Control group was given conventional health education, while observation group was given multi-dimensional medical care integration mode health education. Cognitive scores of GnRH-a combined with add-back therapy, levels of hormone, adverse reactions and levels of bone mineral density (BMD) were compared between two groups. Results Before health education, there were no statistically significant differences in the cognitive scores of GnRH-a combination with add-back therapy between two groups (P > 0.05). After health education, the cognitive scores of GnRH-a combination with add-back therapy in both groups were increased, and observation group was higher than control group, with statistically significant differences (P < 0.05). The levels of follicule-stimulating hormone (FSH), lutropin (LH), estradiol (E2) was decreased in both groups, and the levels of FSH, LH in observation group was lower than those in control group, while the level of E2 in observation group was higher than that in control group, with statistically significant differences (all P < 0.05). The BMD levels of 1-4 lumbar spine (L1-L4) and femoral head in both groups were decreased, and observation group was higher than control group, and the differences were statistically significant (all P < 0.05). The incidence of adverse reactions in observation group were lower than that in control group, and the differences were statistically significants (P < 0.05). Conclusion Ethnic minority patients with uterine leiomyoma in Xinjiang District has low level of cognition of GnRH-a combined with add-back therapy. And multi-dimensional medical care integration mode health education can increase cognition level, improve levels of sex hormones, reduce incidences of adverse reactions and has less influences on bone loss.
朱晔1 弥娟妮2 朱红艳1▲ 何艳1. 新疆地区少数民族子宫肌瘤患者GnRH-a联合反加疗法的认知调查及健康教育新模式探讨[J]. 中国医药导报, 2019, 16(36): 92-95.
ZHU Ye1 MI Juanni2 ZHU Hongyan1▲ HE Yan1. Cognition investigation of GnRH-a in combination with add-back therapy in ethnic minority patients with uterine leiomyoma in Xinjiang District and discussion the new model of health education. 中国医药导报, 2019, 16(36): 92-95.