Expression and clinical significance of serum FFA, β-arrestin2 and RBP4 in patients with type 2 diabetes mellitus
SHA Yifeng1 CAO Xiaojun1 SHEN Limin1 SHI Bimin2 XING Jianping1
1.Department of Endocrinology, Zhangjiagang Hospital Affiliated To Soochow University, Jiangsu Province, Zhangjiagang 215600, China;
2.Department of Endocrinology, the First Affiliated Hospital of Soochow University, Jiangsu Province, Suzhou 215006, China
Abstract：Objective To investigate the expression and clinical significance of serum free fatty acids (FFA), β inhibition of protein 2 (β-arrestin2), retinol-binding protein 4 (RBP4) in patients with type 2 diabetes mellitus (T2DM). Methods From February 2016 to December 2018, 123 T2DM patients admitted to Zhangjiagang Hospital Affiliated To Soochow University (hereinafter referred to as “our hospital”) were selected as the observation group. The observation group was divided into the obese T2DM group (BMI≥28 kg/m2, n = 62) and the non-obese T2DM group (BMI＜28 kg/m2, n = 61) according to body mass index (BMI). In addition, 60 volunteers who came to our hospital for physical examination during the same period were selected as the control group. The serum levels of FFA, β-arrestin2, RBP4 and glucose and lipid metabolism of the three groups were compared. Pearson correlation was used to analyze the correlation between the serum levels of FFA, β-arrestin2 and RBP4 and the level of glucose and lipid metabolism. Results The serum levels of FFA and RBP4 in the T2DM obesity group and the T2DM non-obesity group were higher than those in the control group, and those in the T2DM obesity group were higher than those in the T2DM non-obesity group (P ＜ 0.05). The level of β-arrestin2 in the T2DM obesity group and the T2DM non-obesity group was lower than that in the control group, and that in the T2DM obesity group was lower than that in the T2DM non-obesity group (P ＜ 0.05). The glycosylated hemoglobin (HbA1c), total cholesterol (TC), low density lipoprotein cholesterin (LDL-C), triglyceride (TG), insulin resistance index (HOMA-IR) and BMI in the T2DM obesity group and the T2DM non-obesity group were higher than the control group, and those in the T2DM obesity group were higher than those in the T2DM non-obesity group (P ＜ 0.05). However, there was no statistically significant difference in high-density lipoprotein cholesterol (HDL-C) between the three groups (P ＞ 0.05). Serum FFA and RBP4 of T2DM patients was positively correlated with HbA1c, TC, TG, LDL-C, HOMA-IR and BMI (r ＞ 0，P ＜ 0.05), β-arrestin2 was negatively correlated with HbA1c, TC, TG, LDL-C, HOMA-IR and BMI (r ＜ 0，P ＜ 0.05). FFA, RBP4 and β-arrestin2 were not correlated with HDL-C (P > 0.05). Conclusion In T2DM patients, the serum levels of FFA, β-arrestin2 and RBP4 were all abnormally expressed, which may jointly promote the disease progression of T2DM.
2019, Vol. 16 
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