中老年人群血尿酸水平与急性缺血性脑卒中风险分析

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摘要目的探讨中老年人群血尿酸水平与急性缺血性脑卒中发生风险及其临床意义。方法回顾性分析2015年1月～2017年12月中国人民解放军联勤保障部队第九〇八医院符合研究标准的304例患者资料，其中152例新发急性缺血性脑卒中患者为卒中组，152例匹配的非卒中患者为非卒中组。收集纳入研究患者的临床与生化资料，比较两组患者间的基本信息与临床、生化指标；采用多因素条件Logistic回归分析方法探讨血尿酸水平与急性缺血性脑卒中发生的关系。结果卒中组与非卒中组患者性别、年龄、收缩压、吸烟、饮酒、低密度脂蛋白胆固醇、三酰甘油、总胆固醇、血尿素氮与血糖等指标比较，差异无统计学意义（P ＞ 0.05）；体重指数、白细胞、血小板、高密度脂蛋白胆固醇、血尿酸、血肌酐、谷草转氨酶、同型半胱氨酸等指标比较，差异有统计学意义（P ＜ 0.05）；血尿酸水平对女性缺血性脑卒中发生风险为1.01（95%CI：1.00～1.01，P = 0.027），但血尿酸水平对男性缺血性脑卒中发生风险差异无统计学意义（P ＞ 0.05）。结论女性人群血尿酸水平升高增加急性缺血性脑卒中发生风险，男性风险尚不显著。

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	张萃萍欧阳晓春余小骊潘婕

关键词 ：卒中, 急性缺血性脑卒中, 血尿酸, 多因素分析

Abstract：Objective To investigate the risk and clinical significance of serum uric acid level and acute ischemic stroke in the middle-aged and elderly populations. Methods Retrospective analysis was performed on the data of 304 patients who met the study criteria in the No.908 Hospital of the People′s Liberation Army Joint Logistics Support Force from January 2015 to December 2017, among which 152 new acute ischemic stroke patients were in the stroke group and 152 matched non-stroke patients were in the non-stroke group. The clinical and biochemical data of the included patients were collected, and the basic information, clinical and biochemical indicators between the two groups were compared. Multivariate Logistic regression analysis was used to investigate the relationship between serum uric acid level and acute ischemic stroke. Results There were no significant differences in gender, age, systolic blood pressure, smoking, alcohol consumption, low density lipoprotein cholesterin, triglyceride, total cholesterol, blood urea nitrogen and blood glucose between the stroke group and the non-stroke group (P ＞ 0.05). Body mass index, white blood cells, platelets, high density lipoprotein cholesterol, serum uric acid, serum creatinine, glutamic oxalacetic transaminase, homocysteine and other indicators were compared, and the differences were statistically significant (P ＜ 0.05). The risk of ischemic stroke in females was 1.01 (95%CI: 1.00-1.01, P = 0.027), but there was no statistically significant difference in the risk of ischemic stroke in males (P ＞ 0.05). Conclusion Elevated serum uric acid levels increase the risk of acute ischemic stroke in females, but not significantly in males.

Key words： Stroke Acute ischemic stroke Serum uric acid Multivariate analysis

基金资助:南京军区医学科技创新课题资助项目（11MB015）。

通讯作者: 欧阳晓春（1970-），男，硕士，副主任医师；研究方向：脑血管病、痴呆。

引用本文:

张萃萍欧阳晓春余小骊潘婕. 中老年人群血尿酸水平与急性缺血性脑卒中风险分析[J]. 中国医药导报, 2019, 16(35): 57-60.
ZHANG Cuiping OUYANG Xiaochun YU Xiaoli PANG Jie. Analysis of serum uric acid level and risk of acute ischemic stroke in middle-aged and elderly population. 中国医药导报, 2019, 16(35): 57-60.

链接本文:

http://www.yiyaodaobao.com.cn/CN/ 或 http://www.yiyaodaobao.com.cn/CN/Y2019/V16/I35/57

[1] Mohsin M，Das SN，Haque MF，et al. Serum Uric Acid Level among Acute Stroke Patients [J]. Mymensingh Med J，2016，25（2）：215-220.
[2] Mapoure YN，Ayeah CM，Ba H，et al. The Prognostic Value of Serum Uric Acid in the Acute Phase of Ischemic Stroke in Black Africans [J]. J Stroke Cerebrovasc Dis，2018， 27（3）：783-792.
[3] Wang Z，Lin Y，Liu Y，et al. Serum Uric Acid Levels and Outcomes After Acute Ischemic Stroke [J]. Mol Neurobiol，2016，53（3）：1753-1759.
[4] Huang J，Hu D，Wang Y，et al. Dose-response relationship of serum uric acid levels with risk of stroke mortality [J]. Atherosclerosis，2014，234（1）：1-3.
[5] Khalil MI，Islam MJ，Ullah MA，et al. Association of serum uric acid with ischemic stroke [J]. Mymensingh Med J，2013，22（2）：325-330.
[6] 中华医学会神经病学分会脑血管病学组急性缺血性脑卒中诊治指南撰写组.中国急性缺血性脑卒中诊治指南2010[J].中国医学前沿杂志：电子版，2010，2（4）：50-59，69.
[7] Perge P，Boros AM，Zima E，et al. Hyperuricemia predicts adverse clinical outcomes after cardiac resynchronization therapy [J]. Scand Cardiovasc J，2018，52（5）：250-255.
[8] Chen J，Chen H，Feng J，et al. Association between hyperuricemia and metabolic syndrome in patients suffering from bipolar disorder [J]. BMC Psychiatry，2018，18（1）：390.
[9] Zhong C，Zhong X，Xu T，et al. Sex-Specific Relationship Between Serum Uric Acid and Risk of Stroke： A Dose-Response Meta-Analysis of Prospective Studies [J]. J Am Heart Assoc，2017，6（4）.
[10] Lai YJ，Hsu CY. Is serum uric acid a predictive factor for stroke in men with hypertriglyceridemia? [J]. Bratisl Lek Listy，2019，120（4）：316-319.
[11] Kamei K，Konta T，Hirayama A，et al. Associations between serum uric acid levels and the incidence of nonfatal stroke： a nationwide community-based cohort study [J]. Clin Exp Nephrol，2017，21（3）：497-503.
[12] Kim SY，Guevara JP，Kim KM，et al. Hyperuricemia and risk of stroke：a systematic review and meta-analysis [J]. Arthritis Rheum，2009，61（7）：885-892.
[13] Chen JH，Chuang SY，Chen HJ，et al. Serum uric acid level as an independent risk factor for all-cause，cardiovascular，and ischemic stroke mortality：a Chinese cohort study [J]. Arthritis Rheum，2009，61（2）：225-232.
[14] Yang Y，Zhang Y，Li Y，et al. U-Shaped Relationship Between Functional Outcome and Serum Uric Acid in Ischemic Stroke [J]. Cell Physiol Biochem，2018，47（6）：2369-2379.
[15] 王锦阳.高尿酸血症对急性缺血性脑卒中的双重影响[J].国际神经病学神经外科学杂志，2014，41（2）：142-145.
[16] 李双，李艳波.尿酸与2型糖尿病及其慢性并发症的关系[J].中国医药导报，2017，14（11）：26-29.
[17] Woyesa SB，Hirigo AT，Wube TB. Hyperuricemia and metabolic syndrome in type 2 diabetes mellitus patients at Hawassa university comprehensive specialized hospital，South West Ethiopia [J]. BMC Endocr Disord，2017， 17（1）：76.
[18] 朱德生，管阳太.高尿酸血症与卒中的研究进展[J].中国脑血管病杂志，2011，8（11）：607-612.
[19] 孟媛媛，杨志杰，刘迎春.脑卒中高危人群血清尿酸水平与颈动脉粥样硬化易损斑块的关系：一项横断面调查[J].卒中与神经疾病，2017，24（6）：499-503.
[20] Heikamp E，Dreyer ZE. 50 Years Ago in The Journal of Pediatrics：Prevention and Management of Acute Hyperuricemia in Childhood Leukemia [J]. J Pediatr，2017， 191：178.