Abstract：Autophagy is a metabolic pathway in eukaryotic cells through the lysosome, including the processes of autophagosomes formation, the combination of autophagosomes and lysosomes and autophagosomes degradation. Autophagy in hypexic-ischemia brain damage is activated by different signaling pathways and its role and specific mechanism are unclear. On the one hand, autophagy plays a protective role by regulating the autophagosis-lysosome pathway or affecting apoptosis and necrosis. On the other hand, autophagy may aggravate neurons injury after ischemic/hypoxia by interfacing with apoptosis and pyroptosis. This characteristic may be related to the degree of autophagy, the stage of occurrence, and external factors.
黄林 鲁利群. 细胞自噬与缺氧缺血性脑损伤的研究进展[J]. 中国医药导报, 2019, 16(35): 40-43.
HUANG Lin LU Liqun. Research progress of autophagy and hypoxic-ischemic brain injuries. 中国医药导报, 2019, 16(35): 40-43.
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2019, Vol. 16 
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