Abstract：Objective To investigate clinical efficacy of self-made Yiqi Huoxue Decection adjuvant therapy in the treatment of heart failure after acute myocardial infarction (AMI). Methods Eighty patients with heart failure after AMI admitted to Shenzhen Traditional Chinese Medicine Hospital from June 2015 to February 2019 were divided into control group (40 cases) and study group (40 cases) according to random number table method. The patients in control group were treated with conventional treatment. The patients in study group were treated with self-made Yiqi Huoxue Decoction on the basis of control group. The patients in two groups were treated for 2 weeks continuously. The left ventricular ejection fraction (LVEF), left ventricular end diastolic diameter (LVEDD), central venous pressure (CVP), heart rate (HR), serum levels of high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α), interleukin-10 (IL-10), endothelin (ET), nitric oxide (NO) were measured and compared between two groups before and after treatment. The adverse reactions of two groups during the treatment were observed. Results After treatment, LVEF was higher than that before treatment, LVEDD was less than that before treatment, CVP was lower than that before treatment, HR was slower than that before treatment in two groups; after treatment, LVEF, LVEDD, CVP and HR in study group were significantly improved compared with those in control group, the differences were highly statistically significant (P < 0.01). After treatment, the levels of serum hs-CRP and TNF-α were lower than those before treatment, the level of IL-10 was higher than that before treatment in two groups; after treatment, the levels of serum hs-CRP, TNF-α and IL-10 in study group were significantly improved compared with those in control group, the differences were highly statistically significant (P < 0.01). After treatment, the level of serum ET was lower than that before treatment, the level of serum NO was higher than that before treatment in two groups; after treatment, the levels of ET and NO in study group were significantly improved compared with those in control group, the differences were highly statistically significant (P < 0.01). During treatment, there was no significant difference in incidence of adverse reactions between two groups (P > 0.05). Conclusion Clinical effect of self-made Yiqi Huoxue Decection adjuvant therapy in the treatment of heart failure after AMI is significant, which can significantly improve the cardiac function and inflammatory response, adjust the endothelial function and has good safety.
徐慕娟 王玲 韩钺. 自拟益气活血汤辅助治疗急性心肌梗死后心力衰竭的临床研究[J]. 中国医药导报, 2019, 16(33): 129-132.
XU Mujuan WANG Ling HAN Yue. Clinical research of self-made Yiqi Huoxue Decection adjuvant therapy in the treatment of heart failure after acute myocardial infarction. 中国医药导报, 2019, 16(33): 129-132.
2019, Vol. 16 
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