Abstract:Objective To study the expression and significance of CXC chemokine receptor 1 (CXCR1) and interleukin-17 (IL-17) in patients with inflammatory bowel disease (IBD). Methods The clinical data of 80 patients with IBD admitted to Huizhou Third People′s Hospital from January 2016 to December 2017 was analyzed retrospectively, 70 patients with ulcerative colitis (UC group), 10 patients with Crohn′s disease (CD group), and 50 healthy volunteers who underwent colonoscopy at the same time were selected as control group. The expression of IL-17 and CXCR1 mRNA in serum and intestinal mucosa of each group was compared, and the protein expression of CXCR1 in intestinal mucosa of each group was analyzed. The correlation between the expression of IL-17 and CXCR1 mRNA in serum and in intestinal mucosa of patients was analyzed. Results Compared with the control group, the expression of IL-17mRNA in serum of UC group and CD group were higher (all P < 0.05), but there was no significant difference between UC group and CD group (P > 0.05). There was no significant difference in serum CXCR1 mRNA expression between the two groups (P > 0.05). Compared with the control group, the expression of IL-17 and CXCR1 mRNA in intestinal mucosa of UC group and CD group was higher (P < 0.05). The expression of CXCR1 mRNA in intestinal mucosa of UC group was higher than that of CD group (P < 0.05), however, there was no significant difference in IL-17 mRNA expression between the two groups (P > 0.05). Compared with the control group, the protein expression of CXCR1 in intestinal mucosa of UC group and CD group was higher, and the protein expression of CXCR1 in UC group was higher than that in CD group (P < 0.05). Spearman correlation analysis showed that there was a weak correlation between the expression of IL-17 and CXCR1 in serum and intestinal mucosa (P < 0.05). Conclusion The expression levels of CXCR1 mRNA and IL-17 mRNA in serum and intestinal in IBD patients are higher, and there is a positively correlation between the expression of CXCR1 mRNA and IL-17 mRNA in serum and in intestinal mucosa. It is clinically possible to monitor the levels of CXCR1 and IL-17 to better assist in the treatment of IBD.
蔡清红 马松炎 钟俊锋. 炎症性肠病患者CXCR1、IL-17的表达及其意义[J]. 中国医药导报, 2019, 16(32): 99-102.
CAI Qinghong MA Songyan ZHOGN Junfeng. Expression and significance of CXCR1 and IL-17 in patients with inflammatory bowel disease. 中国医药导报, 2019, 16(32): 99-102.