Effect of low-dose Aspirin combined with Tiaojing Cuyun Pills on follicular blood flow and pregnancy outcome of patients with polycystic ovarian syndrome
ZHAO Yue CHENG Jiaojiao
Department of Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China
Abstract：Objective To study the clinical effect of low dose Aspirin combined with Tiaojing Cuyun Pills on the follicular blood flow and pregnancy outcome of patients with polycystic ovary syndrome (PCOS) and its clinical application value. Methods From September to December 2018, 78 infertility women (107 cycles) with PCOS were selected and they were randomly grouped according to the odd-even of admission number: 38 cases of experimental group were treated with Letrozole (LTZ), Aspirin and Tiaojing Cuyun Pills, while 40 cases of control group were treated with LTZ only. The endometrial thickness, follicles maturation, values of follicle peripheral artery [pulsatility index (PI), resistance index (RI), peak systolic velocity (PSV), end diastolic velocity (EDV)], periodic ovulation rate and periodic pregnancy rate on the day of human chorionic gonadotropin (HCG) administration were measured by B ultrasound, and the clinical intervention value was observed. The patients who failed pregnancy in the control group were reintegrated into the experiment group in the next cycle (n = 29), and the ovulation treatment effect was observed. Results The rate of pregnancy cycle in the experiment group was higher than that in the control group (P < 0.05). Patients who failed pregnancy were given the same intervention as experimental group in the next cycle, compared with before changing medication regimen, PI and RI were significantly lowered, while EDV was significantly increased (P < 0.05), the rate of pregnancy cycle was significantly higher of the same patients. Conclusion Compared with simple Western medicine treatment, low-dose Aspirin combined with Tiaojing Cuyun Pills can effectively improve follicle perifollicular artery blood flow, enhance the oocyte development and clinical pregnancy rate. It is an effective way to help pregnancy.
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2019, Vol. 16 
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