非小细胞肺癌中LncRNA表达的研究现状

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摘要肺癌是目前全世界范围内发病率与死亡率均排在第一的恶性肿瘤。长链非编码RNA（LncRNA）作为一种不能编码蛋白质的非编码RNA分子，广泛参与生物体内细胞的分化、周期调控，许多长链非编码RNA还可发挥促进或抑制肿瘤发生发展的作用。本文将从LncRNA对非小细胞肺癌的细胞分化及肿瘤侵袭转移的调控机制作用、其在诊断与靶向治疗上潜在价值等方面进行综述。

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	杨思琦姚颐宋启斌▲

关键词 ：肺癌, 非小细胞肺癌, 长链非编码RNA, 生物学标志

Abstract：Lung cancer is currently ranked first in both morbidity and mortality of malignant tumors in the world. Long non-coding RNA (LncRNA), as a kind of non-coding RNA molecule that cannot encode proteins, is widely involved in the differentiation and cycle regulation of cells in organisms. Many long non-coding RNA can also play a role in promoting or inhibiting the occurrence and development of tumors. This article will summarize the regulatory mechanism of LncRNA on cell differentiation and tumor invasion and metastasis of non-small cell lung cancer, as well as its potential value in diagnosis and targeted therapy.

Key words： Lung cancer Non-small cell lung cancer Long non-coding RNA Biological marker

基金资助:中华国际医学交流基金会先声临床科研专项基金项目（Z-2014-06-17358）。

通讯作者: ▲通讯作者

引用本文:

杨思琦姚颐宋启斌▲. 非小细胞肺癌中LncRNA表达的研究现状[J]. 中国医药导报, 2019, 16(32): 38-41.
YANG Siqi YAO Yi SONG Qibin▲. Research status of LncRNA expression in non-small cell lung cancer. 中国医药导报, 2019, 16(32): 38-41.

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