Mechanism of Sanqi Oral Liquid in the treatment of diabetic nephropathy based on network pharmacology
LIN Jiarong1 ZHANG Lei2 GUI Dingkun3 ZENG Guixing1 WU Yuchi2 ZOU Chuan2 LIN Qizhan2
1.The Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangdong Province, Guangzhou 510405, China;
2.Department of Nephrology, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Province, Guangzhou 510120, China; 3.Department of Nephrology, the Sixth People′s Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200233, China
Abstract：Objective To explore the mechanism of Sanqi Oral Liquid in the treatment of diabetic nephropathy. Methods According to the ADME characteristics of the drug, TCMSP platform was used to screen the active ingredients and targets of Sanqi Oral Liquid, which was developed with the compound of Sanqi and Huangqi, and the component target network was constructed. Retrieval of diabetic nephropathy related targets based on GeneCards database, DisGeNET database and OMIM database. The target of active drugs, active ingredients and genes was constructed by using the software of Cytoscape, and the target information was analyzed by using the database of DAVID and the biological process and pathway enrichment were analyzed. Results There were 27 active components were screened, involving 191 targets, and 118 potential targets related to disease targets. The therapeutic effect of diabetic nephropathy was mainly achieved by regulating PPARG, IL-6 and age-range signaling pathway, fluid shear stress and atherosclerosis, IL-17 signaling pathway, HIF-1 signaling pathway, etc. Conclusion Sanqi Oral Liquid can treat diabetic nephropathy through multi-target and multi-channel, which provides theoretical basis and scientific basis for explaining its therapeutic mechanism.
林嘉荣1 张蕾2 桂定坤3 曾贵兴1 吴禹池2 邹川2 林启展2. 基于网络药理学三芪口服液治疗糖尿病肾病的作用机制[J]. 中国医药导报, 2019, 16(30): 130-135.
LIN Jiarong1 ZHANG Lei2 GUI Dingkun3 ZENG Guixing1 WU Yuchi2 ZOU Chuan2 LIN Qizhan2. Mechanism of Sanqi Oral Liquid in the treatment of diabetic nephropathy based on network pharmacology. 中国医药导报, 2019, 16(30): 130-135.
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2019, Vol. 16 
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