Relationship between intrauterine device and incidence of ectopic pregnancy：a Meta-analysis
YUAN Shuo1 SHEN Qiuxian2 LU Ruling1 DENG Gaopi1▲
1.Department of Gynecology, the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Province, Guangzhou 510405, China;
2.the First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangdong Province, Guangzhou 510120, China
Abstract：Objective To explore the relationship between intrauterine device (IUD) and ectopic pregnancy using a meta-analysis and provide evidence for prevention and treatment of ectopic pregnancy. Methods From the database built to May 10, 2019, Embase, PudMed, the Cochrane Library, China National Knowledge Infrastructure, WanFang Database, VIP Database were searched for randomized case-control studies on the relationship between IUD retention and ectopic pregnancy. Women with ectopic pregnancy were selected as the case group and women with normal pregnancy were selected as the control group. The number of patients with IUD in both groups were recorded. Data were extracted with 3 researchers independently from literatures that met the inclusion criteria. NOS score was used for literature quality evaluation. The sources of heterogeneity were explored with subgroup analysis or sensitivity analysis. Results A total of 19 case-control studies were included. There were 2736 cases in the case group and 3863 cases in the control group. The results showed that the probability of ectopic pregnancy with the case group was 3.11 times higher than that in the control group, the difference is highly statistically significant (P < 0.000 01). Conclusion IUD is one of the risk factors of ectopic pregnancy.
2019, Vol. 16 
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