Detection and analysis of bone metabolic indexes in elderly female patients with distal radius fractures and discussion of risk factors for recurrent fractures
LI Yan CHANG Junying▲ MU Weilu JIA Dongzhao
Ward 1 of Trauma Department, Shijiazhuang No. 3 Hospital, Hebei Province, Shijiazhuang 050000, China
Abstract：Objective To investigate the bone metabolism of elderly female patients with distal radius fracture and the risk factors of recurrent fracture. Methods From February 2017 to October 2018, retrospective analysis was conducted on the data of 182 elderly female patients with distal radius fracture admitted to Shijiazhuang No. 3 Hospital. Bone metabolism indexes were detected after admission. The risk factors of recurrent fracture were analyzed. Results Patients with serum alkaline phosphatase (ALP), bone gta-protein (BGP), collagen type Ⅰ N terminal peptide (NTX-Ⅰ) level were （37.56±5.83）U/L,（3.89±1.05）μg/L, （38.47±5.56）nmol/L, respectively. The incidence recurrent hair fracture was 18.68%, older age, body mass index (BMI) < 18 kg/m2, BMI > 25 kg/m2, with type 2 diabetes, osteoporosis, with lower limb joint disease, serum ALP ＜ 40 U/L, serum BGP < 4.8 μg/L, serum NTX-Ⅰ > 20 mmol/L, live alone are independent risk factors for recurrence of bone (OR = 5.512, 6.265, 5.697, 6.659, 7.776, 6.062, 7.367, 6.699, 6.966, 7.135, P ＜ 0.05). Bone grafting, early load exercise, and calcium salt use were all independent protective factors for recurrent fractures (OR = 0.511, 0.457, 0.475, P ＜ 0.05). Conclusion Elderly women with distal radius fracture are often accompanied by abnormal bone metabolism, and advanced age can increase the risk of recurrent fracture. Abnormal bone metabolism is an independent risk factor, while bone grafting is a protective factor.
李炎 常军英▲ 穆卫庐 贾东昭. 老年女性桡骨远端骨折患者的骨代谢指标检测分析及再发骨折的危险因素探讨[J]. 中国医药导报, 2019, 16(30): 89-92.
LI Yan CHANG Junying▲ MU Weilu JIA Dongzhao. Detection and analysis of bone metabolic indexes in elderly female patients with distal radius fractures and discussion of risk factors for recurrent fractures. 中国医药导报, 2019, 16(30): 89-92.
[1] Yian E，Zhou H，Schreiber A，et al. Early Hospital Readmission and Mortality Risk after Surgical Treatment of Proximal Humerus Fractures in a Community-Based Health Care Organization [J]. Perm J，2016，20（1）：47-52.
[2] Liu Q，Cao J，Kong J. Effects of Percutaneous Kyphoplasty on Bone Metabolism and Oxidative Stress in Elderly Patients with Osteoporotic Spinal Fractures [J]. J Coll Physicians Surg Pak，2019，29（1）：37-40.
[3] Alshamrani K，Messina F，Offiah AC. Is the Greulich and Pyle atlas applicable to all ethnicities? A systematic review and meta-analysis [J]. Eur Radiol，2019，29（6）：2910-2923.
[4] 张孜君，赵文，赵玺，等.二次骨折风险评价：老年女性髋部骨折后6-12个月骨密度及骨代谢变化[J].中国组织工程研究，2013，17（50）：8635-8640.
[5] Sabapathippillai S，Lekamwasam S. Prior fracture and refracture among patients admitted with hip fracture：Data from a regional hip fracture registry in Sri Lanka [J]. Int J Rheum Dis，2018，21（12）：2119-2121.
[6] 陈龙弟，张宇.桡骨远端骨折合并各类腕骨骨折的发生率、危险因素及治疗分析[J].实用临床医药杂志，2017， 21（7）：186-187.
[7] Schnell AD，Curtis JR，Saag KG. Importance of Recent Fracture as Predictor of Imminent Fracture Risk [J]. Curr Osteoporos Rep，2018，16（6）：738-745.
[8] Song W，Intrator O，Lee S，et al. Antihypertensive Drug Deintensification and Recurrent Falls in Long-Term Care [J]. Health Serv Res，2018，53（6）：4066-4086.
[9] Ueda K，Suekane S，Hirano T，et al. Efficacy of Axitinib as Second-line Treatment in Locally Advanced and Metastatic Renal Cell Carcinoma [J]. Anticancer Res，2018，38（9）：5387-5392.
[10] Treister-Goltzman Y，Friger M，Peleg R. Does primary lactase deficiency reduce bone mineral density in postmenopausal women? A systematic review and meta-analysis [J]. Osteoporos Int，2018，29（11）：2399-2407.
[11] 李晓莲，李华，张庆英，等.汕头市社区中老年人骨质疏松症患病情况及影响因素研究[J].中国医药，2017，12（2）：271-275.
[12] 朱星华，郭勇，张智海.社区中老年居民骨质疏松症认知度调查[J].中国现代医生，2017，55（22）：117-120，133.
[11] 李新萍，李晓玉，李宁，等.老年骨质疏松患者髋部骨折术前后骨转换生化标志物的变化[J].中华骨质疏松和骨矿盐疾病杂志，2017，10（4）：320-327.
[12] Touw WA，Ueland T，Bollerslev J，et al. Association of Circulating Wnt Antagonists With Severe Abdominal Aortic Calcification in Elderly Women [J]. J Endocr Soc，2017，1（1）：26-38.
[13] Stone KL，Lui LY，Christen WG，et al. Effect of Combination Folic Acid，Vitamin B（6） ，and Vitamin B（12） Supplementation on Fracture Risk in Women：A Randomized，Controlled Trial [J]. J Bone Miner Res，2017，32（12）：2331-2338.
[14] Huta-Osiecka A，Kasprzak Z，Wochna K，et al. Serum 25-hydroxyvitamin D concentrations and selected diet components in postmenopausal women [J]. Acta Sci Pol Technol Aliment，2017，16（4）：443-449.
[15] 孔德策，杨铁毅，邵进，等.50-60岁绝经后骨折女性25（OH）D3和骨密度、骨代谢指标的关系研究[J].中国骨质疏松杂志，2017，23（2）：191-196.
[16] Macêdo LLG，Carvalho CMRG，Cavalcanti JC，et al. Vitamin B12，bone mineral density and fracture risk in adults：A systematic review [J]. Rev Assoc Med Bras （1992），2017，63（9）：801-809.
[17] Watanabe R，Shiraki M，Saito M，et al. Restrictive pulmonary dysfunction is associated with vertebral fractures and bone loss in elderly postmenopausal women [J]. Osteoporos Int，2018，29（3）：625-633.
[18] Purnamasari D，Puspitasari MD，Setiyohadi B，et al. Low bone turnover in premenopausal women with type 2 diabetes mellitus as an early process of diabetes-associated bone alterations：a cross-sectional study [J]. BMC Endocr Disord，2017，17（1）：72.
[19] Chisalita SI，Chong LT，Wajda M，et al. Association of Insulin-like Growth Factor-1，Bone Mass and Inflammation to Low-energy Distal Radius Fractures and Fracture Healing in Elderly Women Attending Emergency Care [J]. Orthop Surg，2017，9（4）：380-385.
[20] 唐雯菁，洪维，陈敏敏，等.上海社区老年人椎体骨折的患病率与危险因素分析[J].中华内分泌代谢杂志，2018， 34（6）：498.
[21] Oka R，Ohira M，Suzuki S，et al. Fracture risk assessment tool （FRAX） and for the diagnosis of osteoporosis in Japanese middle-aged and elderly women：Chiba bone survey [J]. Endocr J，2018，65（2）：193-202.
2019, Vol. 16 
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