Relationship between clinical features of different phenotypes of refractory asthma and peripheral blood cells
CONG Li1 ZENG Yun2 CHEN Liping1▲ WU Chao1
1.Department of Respiratory and Critical Care Medicine, Xinjiang Uygur Autonomous Region People′s Hospital, Xinjiang Uygur Autonomous Region, Urumqi 830001, China;
2.Department of Respiratory and Gastroentry, Xinjiang Uygur Autonomous Region Children′s Hospital, Xinjiang Uygur Autonomous Region, Urumqi 830001, China
Abstract：Objective To explore and analyze the correlation between different phenotypes of refractory asthma and peripheral blood cells. Methods Eighty-eight patients with refractory asthma admitted to Xinjiang Uygur Autonomous Region People′s Hospital from May 2016 to May 2018 were selected as subjects, while they were enrolled in the sputum cytology. According to different airway inflammation phenotypes, the patients were classified in acidic granulocyte type, neutrophil type, mixed cell type and oligocytic type. The lung function indexes and the peripheral blood counts of patients with different airway inflammation phenotypes were compared. Results Forced expiratory volume in one second (FEV1), FEV1/forced vital capacity(FVC), fractional exhaled nitirc oxide(FeNO) in acidic granulocyte type and mixed cell type patients were significantly higher than those in neutrophil type, and the differences were statistically significant (P ＜ 0.05). FEV1、FEV1/FVC in oligocytic type patients were significantly higher than those in neutrophil type, while FeNo was lower than that in neutrophil type, and the differences were statistically significant (P ＜ 0.05). Neutrophils in acidic granulocyte type and mix cell type patients were significantly lower than those in neutrophil type, while eosinophils were significantly higher than those in neutrophil type, and the differences were statistically significant (P ＜ 0.05). Neutrophils in oligocytic type patients were lower than that in neutrophil type, while lymphocytes were significantly higher than those in neutrophil type, and the differences were statistically significant (P ＜ 0.05). Conclusion There are four phenotypes of airway inflammation in refractory asthma. Among them, the pulmonary function of neutrophil type is poor, and the levels of eosinophils and neutrophils in peripheral blood cells are correlated in assessing the inflammatory phenotype of asthma.
2019, Vol. 16 
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