前列腺癌组织中VEGF-C、Bcl-xl的mRNA表达及与临床病理特征及预后的关系

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摘要目的研究前列腺癌（PCa）组织中血管内皮生长因子C（VEGF-C）mRNA与B细胞淋巴瘤/白血病-xl（Bcl-xl）mRNA的表达，分析两者表达与PCa患者临床病理特征及预后的相关性。方法收集2014年1月～2016年6月广东省粤北人民医院经手术获取的132例PCa组织及40例良性前列腺增生（BPH）组织，采用实时定量PCR法检测PCa组织及BPH组织中VEGF-C mRNA、Bcl-xl mRNA的表达，分析两者表达与临床病理特征关系；采用Kaplan-Meier生存分析探究不同VEGF-C mRNA、Bcl-xl mRNA表达与患者预后的关系。结果 PCa组织中VEGF-C mRNA、Bcl-xl mRNA的相对表达量均显著高于BPH组织（均P ＜ 0.05）。VEGF-C mRNA与Bcl-xl mRNA的表达呈正相关（r = 0. 637，P ＜ 0.05）。不同年龄、Gleason评分、入院PSA的患者PCa组织中VEGF-C mRNA、Bcl-xl mRNA表达比较，差异均无统计学意义（均P ＞ 0.05）。不同TNM分期及是否存在远处转移的的患者PCa组织中VEGF-C mRNA、Bcl-xl mRNA表达比较，差异均有统计学意义（均P ＜ 0.05）。高表达VEGF-C mRNA、Bcl-xl mRNA患者3年总体生存率分别明显低于低表达VEGF-C、Bcl-xl患者（均P ＜ 0.05）。结论 PCa组织中VEGF-C mRNA、Bcl-xl mRNA表达增高与肿瘤TNM分期和是否伴有远处转移有关，VEGF-C mRNA、Bcl-xl mRNA有可能成为新的PCa诊断和治疗的生物学靶点。

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	韩跃辅陈东彭敛黄洪才

关键词 ：前列腺癌, VEGF-C, Bcl-xl, 临床意义

Abstract：Objective To study the expression of vascular endothelial growth factor C (VEGF-C) mRNA and B cell lymphoma/leukemia-xl (Bcl-xl) mRNA in prostatic carcinoma (PCa) tissues and analyze the correlation between their expressions and clinical pathological characteristics and prognosis of PCa patients. Methods One hundred and thirty-two cases of PCa and forty cases of benign prostatic hyperplasia (BPH) tissue obtained by surgery in Yuebei People′s Hospital Guangdong Province from January 2014 to June 2016 were collected. Real-time quantitative PCR was used to detect the expressions of VEGF-C mRNA and Bcl-xl mRNA in PCa and BPH tissues, and the relationship between their expressions and clinical pathological characteristics was analyzed. Kaplan-meier survival analysis was used to explore the difference in prognosis of patients with different VEGF-C mRNA and Bcl-xl mRNA expressions. Results The relative expressions of VEGF-C mRNA and Bcl-xl mRNA in PCa tissues were significantly higher than those in BPH tissues (all P ＜ 0.05). The expression of VEGF-C mRNA was positively correlated with the expression of Bcl-xl mRNA (r = 0.637，P ＜ 0.05). There was no significant difference in the expression of VEGF-C mRNA and Bcl-xl mRNA in PCa tissues of patients with different age, Gleason score and admission to PSA (all P ＞ 0.05). The expression of VEGF-C mRNA and Bcl-xl mRNA in PCa tissues of patients with different TNM stages and with or without distant metastasis was statistically significant (all P ＜ 0.05). The 3-year overall survival rate of patients with high expression of VEGF-C mRNA and Bcl-xl mRNA was significantly lower than that of patients with low expression of VEGF-C mRNA and Bcl-xl mRNA (all P ＜ 0.05). Conclusion The increased expression of VEGF-C mRNA and Bcl-xl mRNA in PCa tissue is related to the TNM stage of tumor and whether it is accompanied by distant metastasis. VEGF-C mRNA and Bcl-xl mRNA may become new biological targets for PCa diagnosis and treatment.

Key words： Prostatic carcinoma Vascular endothelial growth factor C B cell lymphoma/leukemia-xl Clinical significance

基金资助:广东省自然科学基金项目（2015A03031038）。

作者简介: 韩跃辅（1975.9-），男，硕士，副主任医师；研究方向：泌尿系肿瘤。

引用本文:

韩跃辅陈东彭敛黄洪才. 前列腺癌组织中VEGF-C、Bcl-xl的mRNA表达及与临床病理特征及预后的关系[J]. 中国医药导报, 2019, 16(29): 96-99,103.
HAN Yuefu CHEN Dong PENG Lian HUANG Hongcai. mRNA expression of VEGF-C and Bcl-xl in prostatic carcinoma tissues and their correlation with clinical pathological characteristics and prognosis. 中国医药导报, 2019, 16(29): 96-99,103.

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http://www.yiyaodaobao.com.cn/CN/ 或 http://www.yiyaodaobao.com.cn/CN/Y2019/V16/I29/96

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