Abstract：Acquired immune deficiency syndrome (AIDS) patients often chronic diarrhea as a prominent clinical manifestations. The etiology of AIDS diarrhea in addition to the combination of intestinal opportunistic infection, combined with intestinal tumor, also includes human immunodeficiency virus (HIV) direct injury caused by HIV enteropathy or idiopathic AIDS enteropathy. In clinical practice, AIDS enteropathy is easy to be misdiagnosed as inflammatory bowel disease (IBD) due to patients′ concealed medical history and lack of specific signs of intestinal manifestations under endoscope. However, both HIV infection and IBD are immunologic inadequacy, and there is a close correlation between IBD and HIV infection. This paper reviews the clinical features of AIDS enteropathy, the differential diagnosis of IBD, and the relationship between HIV infection and IBD.
刘欢宇 冉艳 米琛 厉英超. 艾滋病肠病与炎症性肠病的鉴别和作用关系研究进展[J]. 中国医药导报, 2019, 16(29): 41-44.
LIU Huanyu RAN Yan MI Chen LI Yingchao. Research progress on the differential diagnosis and functional relationship between AIDS enteropathy and inflammatory bowel disease. 中国医药导报, 2019, 16(29): 41-44.
[1] Kotler DP，Gaetz HP，Lange M，et al. Enteropathy associated with the acquired immunodeficiency syndrome [J]. Ann Intern Med，1984，101（4）：421-428.
[2] Dubé C，Rabeneck L. Seven-day postcolonoscopy emergency department visits：What do they really measure？ [J]. Gastrointest Endosc，2018，87（2）：526-528.
[3] Cello JP，Day LW. Idiopathic AIDS enteropathy and treatment of gastrointestinal opportunistic pathogens [J]. Gastroenterology，2009，136（6）：1952-1965.
[4] Motta I，Trunfio M，Calcagno A，et al. Undetectable antimicrobial plasma concentrations in an HIV-positive patient with protein-losing enteropathy and chylothorax during Mycobacterium genavense and Leishmania abdominal infections [J]. J Antimicrob Chemother，2018，73（2）：546-548.
[5] Blanshard C，Francis N，Gazzard BG. Investigation of chronic diarrhoea in acquired immunodeficiency syndrome. A prospective study of 155 patients [J]. Gut，1996，39（6）：824-832.
[6] Gutiérrez-Delgado EM，Villanueva-Lozano H，García Rojas-Acosta MJ，et al. A case report of small bowel perforation secondary to cytomegalovirus related immune reconstitution inflammatory syndrome in an AIDS patient [J]. Ann Med Surg（Lond），2016，13：20-23.
[7] Morikubo H，Saito D，Miura M，et al. A Case of an HIV-infected patient with confirmed overlapping complications of severe amebic colitis and CMV enteritis [J]. Intern Med，2018，57（13）：1855-1860.
[8] Kawazoe A，Nagata N. Intestinal tuberculosis in an HIV-infected patient with advanced immunosuppression [J]. Clin Gastroenterol Hepatol，2012，10（9）：A24.
[9] 孙承民，王贞彪，李坪，等.33例AIDS患者肠镜表现和临床特征分析[J].中华消化内镜杂志，2010，27（10）：542-544.
[10] 谢荣华，欧阳珊珊.HIV/AIDS相关慢性腹泻患者几种肠道寄生虫感染检测分析[J].中华微生物学和免疫学杂志，2013，33（5）：369-370.
[11] 张月宁，赵媛，李鹏，等.HIV感染者结肠镜特点分析[J].胃肠病学和肝病学杂志，2018，27（1）：62-65.
[12] Rezende RE，Kahwage RL，da Costa TV，et al. Upper gastrointestinal Kaposi′s sarcoma in HIV-infected patients：ten years of endoscopy observation at a single Brazilian center [J]. Int J Infect Dis，2015，39：110-115.
[13] Kasapovic A，Boesecke C，Schwarze-Zander C，et al. Screening colonoscopy in HIV-infected patients：high rates of mucosal abnormalities in a German HIV-infected cohort [J]. HIV Med，2014，15（3）：175-181.
[14] Amadi B，Besa E，Zyambo K，et al. Impaired Barrier Function and Autoantibody Generation in Malnutrition Enteropathy in Zambia [J]. EBioMedicine，2017，22：191-199.
[15] Dikman AE，Schonfeld E，Srisarajivakul NC，et al. Human immunodeficiency virus-associated diarrhea：still an issue in the era of antiretroviral therapy [J]. Dig Dis Sci，2015，60（8）：2236-2245.
[16] 雷洁，李金程，丁海波，等.HAART治疗后不同免疫应答人群T细胞特征研究[J].免疫学杂志，2019，35（2）：143-150.
[17] Ciampa BP，Reyes Ramos E，Borum M，et al. The Emerging Therapeutic Role of Medical Foods for Gastrointestinal Disorders [J]. Gastroenterol Hepatol（NY），2017，13（2）：104-115.
[18] Sakai E，Higurashi T，Ohkubo H，et al. Investigation of small bowel abnormalities in HIV-infected patients using capsule endoscopy [J]. Gastroenterol Res Pract，2017， 2017：1932647.
[19] Moso MA，Anderson JL，Adikari S，et al. HIV latency can be established in proliferating and nonproliferating resting CD4+T cells in vitro：implications for latency reversal [J]. AIDS，2019，33（2）：199-209.
[20] Croteau JD，Engle EL，Queen SE，et al. Marked Enteropathy in an Accelerated Macaque Model of AIDS [J]. Am J Pathol，2017，187（3）：589-604.
[21] James SP. Remission of Crohn′s disease after human immunodeficiency virus infection [J]. Gastroenterology，1988， 95（6）：1667-1669.
[22] Pospai D，René E，Fiasse R，et al. Crohn′s disease stable remission after human immunodeficiency virus infection [J]. Dig Dis Sci，1998，43（2）：412-419.
[23] Viazis N，Vlachogiannakos J，Georgiou O，et al. Course of inflammatory bowel disease in patients infected with human immunodeficiency virus [J]. Inflamm Bowel Dis，2010，16（3）：507-511.
[24] 中华医学会消化病学分会炎症性肠病学组.炎症性肠病诊断与治疗的共识意见（2018年·北京）[J].中国实用内科杂志，2018，38（9）：796-813.
[25] Magro F，Gionchetti P，Eliakim R，et al. Third European evidence-based consensus on diagnosis and management of ulcerative colitis. Part 1： Definitions，diagnosis，extra-intestinal manifestations，pregnancy，cancer surveillance，surgery，and ileo-anal pouch disorders [J]. J Crohns Colitis，2017，11（6）：649-670.
[26] 王译葵，陈晓晨，王继宝，等.德宏傣族景颇族自治州2016年HIV/HCV合并感染者HCV分子传播簇分析[J].中华流行病学杂志，2019，40（2）：191-195.
[27] Brunasso AM，Puntoni M，Gulia A，et al. Safety of anti-tumour necrosis factor agents in patients with chronic hepatitis C infection：a systematic review [J]. Rheumatology（Oxford），2011，50（9）：1700-1711.
2019, Vol. 16 
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