Research progress of leukotrienes associated with the atherosclerosis
HUANG Jiaxin1 TIAN Ji1 NI Wei2 DU Wenwen3 HUANG Rongzeng1 SONG Chengwu1 XIE Yun1 JIN Shuna4
1.College of Pharmacy, Hubei University of Chinese Medicine, Hubei Province, Wuhan 430065, China;
2.Department of Laboratory, Hubei Provincial Hospital of TCM, Hubei Province, Wuhan 430060, China;
3.Department of Pharmacy, Jiaozuo People′s Hospital, He′nan Province, Jiaozuo 454000, China;
4.School of Public Health, Huazhong University of Science and Technology, Hubei Province, Wuhan 430030, China
Abstract：Lukotrienes (LTs) are inflammatory mediators of eicosanoids in leukocytes, which are formed by arachidonic acid and eicosapentaenoic acid through the oxidation of arachidonic acid 5-lipoxygenase. This article gives a brief overview of physical and chemical properties of LTs, then details the significance of clinical monitoring between LTs and atherosclerosis through the lipoxygenase pathway metabolic processes and their products. Besides, the associations between LTs and atherosclerosis in the reported animal and human studies are assessed, which can provide suggestion for screening LTs-based disease biomarkers and be as the available reference of their new clinically targeted treatment options.
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2019, Vol. 16 
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