Abstract：Malignant tumers are one of the diseases with the highest morbidity and mortality in the world. In recent years, tumor immunotherapy as a targeted therapy using its own immune system to induce anti-tumor effects has attracted more and more attention. Natural killer (NK) cells are lymphoid cells with a variety of immunological functions. They are important members of natural immunity. NK cells can directly or indirectly kill tumor cells through cytotoxicity and immune regulation, and play an important role in immune surveillance. However, there are many mechanisms in many malignant tumors to help the tumor escape the recognition and killing of NK cells, leading to immune escape. Therefore, how to restore and enhance the anti-tumor effect of NK cells is particularly important. Traditional Chinese medicine can regulate a variety of immune cell functions in the treatment of malignant tumors. This article reviews how tumor cells escape NK cells immune surveillance and the regulation of NK cells by traditional Chinese medicine.
孙御芳 倪中亚 王莉新 朱诗国. 基于NK细胞的肿瘤免疫逃逸及中医药对NK的免疫调节作用[J]. 中国医药导报, 2019, 16(28): 52-55.
SUN Yufang NI Zhongya WANG Lixin ZHU Shiguo. Tumor immune escape from NK cells and immunomodulatory effects of traditional Chinese medicine on NK cells. 中国医药导报, 2019, 16(28): 52-55.
[1] Bray F，Ferlay J，Soerjomataram I，et al. Global cancer statistics 2018：GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries [J]. CA Cancer J Clin，2018，68（6）：394-424.
[2] Wayteck L，Breckpot K，Demeester J，et al. A personalized view on cancer immunotherapy [J]. Cancer Lett，2014，352（1）：113-125.
[3] Fang F，Xiao W，Tian Z. NK cell-based immunotherapy for cancer [J]. Semin Immunol，2017，31：37-54.
[4] Paul S，Kulkarni N，Shilpi，et al. Intratumoral natural killer cells show reduced effector and cytolytic properties and control the differentiation of effector Th1 cells [J]. Oncoimmunology，2016，5（12）：e1235106.
[5] Sconocchia G，Eppenberger S，Spagnoli GC，et al. NK cells and T cells cooperate during the clinical course of colorectal cancer [J]. Oncoimmunology，2014，3（8）：e952197.
[6] Smyth MJ，Crowe NY，Godfrey DI. NK cells and NKT cells collaborate in host protection from methylcholanthrene-induced fibrosarcoma [J]. Int Immunol，2001，13（4）：459-463.
[7] O′Sullivan T，Saddawi-Konefka R，Vermi W，et al. Cancer immunoediting by the innate immune system in the absence of adaptive immunity [J]. J Exp Med，2012，209（10）：1869-1882.
[8] Bottos A，Gotthardt D，Gill JW，et al. Decreased NK-cell tumour immunosurveillance consequent to JAK inhibition enhances metastasis in breast cancer models [J]. Nat Commun，2016，7：12258.
[9] Baragano Raneros A，Suarez-Alvarez B，Lopez-Larrea C. Secretory pathways generating immunosuppressive NKG2D ligands：New targets for therapeutic intervention [J]. Oncoimmunology，2014，3：e28497.
[10] Zingoni A，Cecere F，Vulpis E，et al. Genotoxic Stress Induces Senescence-Associated ADAM10-Dependent Release of NKG2D MIC Ligands in Multiple Myeloma Cells [J]. J Immunol，2015，195（2）：736-748.
[11] Fionda C，Soriani A，Zingoni A，et al. NKG2D and DNAM-1 Ligands：Molecular Targets for NK Cell-Mediated Immunotherapeutic Intervention in Multiple Myeloma [J]. Biomed Res Int，2015，2015：178698.
[12] Liu G，Lu S，Wang X，et al. Perturbation of NK cell peripheral homeostasis accelerates prostate carcinoma meta-stasis [J]. J Clin Invest，2013，123（10）：4410-4422.
[13] Reiners KS，Topolar D，Henke A，et al. Soluble ligands for NK cell receptors promote evasion of chronic lymphocytic leukemia cells from NK cell anti-tumor activity [J]. Blood，2013，121（18）：3658-3665.
[14] Varbanova V，Naumova E，Mihaylova A. Killer-cell immunoglobulin-like receptor genes and ligands and their role in hematologic malignancies [J]. Cancer Immunol Immunother，2016，65（4）：427-440.
[15] Sun C，Xu J，Huang Q，et al. High NKG2A expression contributes to NK cell exhaustion and predicts a poor prognosis of patients with liver cancer [J]. Oncoimmunology，2016，6（1）：e1264562.
[16] Tang PM，Zhou S，Meng XM，et al. Smad3 promotes cancer progression by inhibiting E4BP4-mediated NK cell development [J]. Nat Commun，2017，8：14677.
[17] Fujii R，Jochems C，Tritsch SR，et al. An IL-15 superagonist/IL-15Ralpha fusion complex protects and rescues NK cell-cytotoxic function from TGF-beta1-mediated immunosuppression [J]. Cancer Immunol Immunother，2018，67（4）：675-689.
[18] Della Chiesa M，Carlomagno S，Frumento G，et al. The tryptophan catabolite L-kynurenine inhibits the surface expression of NKp46- and NKG2D-activating receptors and regulates NK-cell function [J]. Blood，2006，108（13）：4118-4125.
[19] Song H，Park H，Kim YS，et al. L-kynurenine-induced apoptosis in human NK cells is mediated by reactive oxygen species [J]. Int Immunopharmacol，2011，11（8）：932-938.
[20] Park A，Lee Y，Kim MS，et al. Prostaglandin E2 Secreted by Thyroid Cancer Cells Contributes to Immune Escape Through the Suppression of Natural Killer （NK） Cell Cytotoxicity and NK Cell Differentiation [J]. Front Immunol，2018，9：1859.
[21] Stiff A，Trikha P，Mundy-Bosse B，et al. Nitric Oxide Production by Myeloid-Derived Suppressor Cells Plays a Role in Impairing Fc Receptor-Mediated Natural Killer Cell Function [J]. Clin Cancer Res，2018，24（8）：1891-1904.
[22] Krneta T，Gillgrass A，Poznanski S，et al. M2-polarized and tumor-associated macrophages alter NK cell phenotype and function in a contact-dependent manner [J]. J Leukoc Biol，2017，101（1）：285-295.
[23] Biswas SK，Mantovani A. Macrophage plasticity and interaction with lymphocyte subsets：cancer as a paradigm [J]. Nat Immunol，2010，11（10）：889-896.
[24] Balsamo M，Scordamaglia F，Pietra G，et al. Melanoma-associated fibroblasts modulate NK cell phenotype and antitumor cytotoxicity [J]. Proc Natl Acad Sci U S A，2009，106（49）：20847-20852.
[25] Li T，Yang Y，Hua X，et al. Hepatocellular carcinoma-associated fibroblasts trigger NK cell dysfunction via PGE2 and IDO [J]. Cancer Lett，2012，318（2）：154-161.
[26] Li Y，Sun R. Tumor immunotherapy：New aspects of natural killer cells [J]. Chin J Cancer Res，2018，30（2）：173-196.
[27] 李浩，景小雪.浅谈中医治疗恶性肿瘤的主要法则[J].世界最新医学信息文摘，2018，18（44）：140，142.
[28] 龚贵香，汤健.补气健脾清热中药对恶性肿瘤患者NK细胞活性及生活质量的影响[J].现代肿瘤医学，2015， 23（21）：3173-3175.
[29] 兰红云，郑晓丹，郭钰琪，等.IL-17D调控肺脏NK细胞募集及黄芪的促进作用[J].中国免疫学杂志，2018，34（3）：393-397.
[30] Han R，Wu WQ，Wu XP，et al. Effect of total flavonoids from the seeds of Astragali complanati on natural killer cell function [J]. J Ethnopharmacol，2015，173：157-165.
[31] Houh YK，Kim KE，Park S，et al. The Effects of Artemisinin on the Cytolytic Activity of Natural Killer（NK）Cells [J]. Int J Mol Sci，2017，18（7）.
[32] Luo Y，Wu J，Zhu X，et al. NK Cell-Dependent Growth Inhibition of Lewis Lung Cancer by Yu-Ping-Feng，an Ancient Chinese Herbal Formula [J]. Mediators Inflamm，2016，2016：3541283.
[33] Yao C，Ni Z，Gong C，et al. Rocaglamide enhances NK cell-mediated killing of non-small cell lung cancer cells by inhibiting autophagy [J]. Autophagy，2018，14（10）：1831-1844.
[34] Lian GY，Wang QM，Tang PM，et al. Combination of Asiatic Acid and Naringenin Modulates NK Cell Anti-cancer Immunity by Rebalancing Smad3/Smad7 Signaling [J]. Mol Ther，2018，26（9）：2255-2266.
[35] 臧福才，刘明月，刘敏，等.不同行为特征肺癌小鼠血管内皮生长因子表达及NK细胞的活性差异研究[J].中国医药导报，2018，15（15）：18-21，封4.
2019, Vol. 16 
京公网安备 11010502046598号