Effect of Levetiracetam on epilepsy in children and its effect on cognitive function
XING Hongyu1 LIU Pisong2 YANG Yihai3 HAN Hong4
1.Department of Pediatrics, Shanxi Medical University, Shanxi Province, Taiyuan 030001, China;
2.Department of Pediatric Intensive Care Medicine, the First People′s Hospital of Datong, Shanxi Province, Datong 037000, China;
3.Department of Seven Pediatrics, the First People′s Hospital of Datong, Shanxi Province, Datong 037000, China;
4.Department of Neurology, Children′s Hospital Shanxi, Shanxi Province, Taiyuan 030001, China
Abstract：Objective To investigate the efficacy and safety of Levetiracetam in the treatment of epilepsy in children and its effect on cognitive function. Methods From February 2018 to January 2019, 96 pediatric epilepsy patients admitted to the Outpatient Department of Pediatrics and Neurology of Shanxi Children′s Hospital were selected as the study objects. According to the random number table method, the patients were divided into the observation group and the control group, each group with 48 cases. The observation group was given Levethracetam Tablets orally alone, the control group was given Oxazepine in combination on this basis. Both groups were treated for 16 weeks. Clinical efficacy, improvement of EEG before and after treatment, and occurrence of adverse reactions during treatment were compared between the two groups, and cognitive function of the children were evaluated. Results After 16 weeks of intervention, there was no statistically significant difference in clinical efficacy and EEG efficacy between two groups (P ＞ 0.05). The incidence of adverse reactions in the observation group was lower than that in the control group (P ＜ 0.05). Operational intelligence quotient (PIQ), verbal intelligence quotient (VIQ), and full intelligence quotient (FIQ) scores of the two groups were all increased after treatment (all P ＜ 0.05). After treatment, FIQ score of the observation group was lower that of the control group (P ＜ 0.05). There was no significant difference in PIQ and VIQ between the two groups after treatment (P ＞ 0.05). Conclusion The treatment effect of Levetiracetam alone in children with epilepsy is equivalent to that of Ocasepine, which can effectively improve the clinical symptoms, enhance the cognitive function of children, reduce the incidence of adverse reactions, and is relatively safe.
幸鸿宇1 刘丕松2 杨一海3 韩虹4. 左乙拉西坦治疗小儿癫痫的效果及对认知功能的影响[J]. 中国医药导报, 2019, 16(27): 122-125.
XING Hongyu1 LIU Pisong2 YANG Yihai3 HAN Hong4. Effect of Levetiracetam on epilepsy in children and its effect on cognitive function. 中国医药导报, 2019, 16(27): 122-125.
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2019, Vol. 16 
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